File size: 133,704 Bytes
4302cb8 e517cb0 4302cb8 d1349b0 4302cb8 4a99b68 e497f23 4302cb8 3e85cc4 4302cb8 e517cb0 4302cb8 d1349b0 4302cb8 5b2211e 4302cb8 3e85cc4 4302cb8 d1349b0 4302cb8 e497f23 4302cb8 490c9ea 4302cb8 3e85cc4 4302cb8 d1349b0 4302cb8 e497f23 4302cb8 490c9ea 4302cb8 90eda61 244e6a1 f13c482 90eda61 d1349b0 4302cb8 90eda61 244e6a1 f13c482 90eda61 d1349b0 4302cb8 3e85cc4 4302cb8 d1349b0 4302cb8 6485961 4302cb8 e497f23 4a99b68 4302cb8 4a99b68 4302cb8 e497f23 4302cb8 e517cb0 4302cb8 cbfcbde 4302cb8 e517cb0 4302cb8 490c9ea 4302cb8 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 728 729 730 731 732 733 734 735 736 737 738 739 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755 756 757 758 759 760 761 762 763 764 765 766 767 768 769 770 771 772 773 774 775 776 777 778 779 780 781 782 783 784 785 786 787 788 789 790 791 792 793 794 795 796 797 798 799 800 801 802 803 804 805 806 807 808 809 810 811 812 813 814 815 816 817 818 819 820 821 822 823 824 825 826 827 828 829 830 831 832 833 834 835 836 837 838 839 840 841 842 843 844 845 846 847 848 849 850 851 852 853 854 855 856 857 858 859 860 861 862 863 864 865 866 867 868 869 870 871 872 873 874 875 876 877 878 879 880 881 882 883 884 885 886 887 888 889 890 891 892 893 894 895 896 897 898 899 900 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 1022 1023 1024 1025 1026 1027 1028 1029 1030 1031 1032 1033 1034 1035 1036 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070 1071 1072 1073 1074 1075 1076 1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 1101 1102 1103 1104 1105 1106 1107 1108 1109 1110 1111 1112 1113 1114 1115 1116 1117 1118 1119 1120 1121 1122 1123 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 1136 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 1171 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 1201 1202 1203 1204 1205 1206 1207 1208 1209 1210 1211 1212 1213 1214 1215 1216 1217 1218 1219 1220 1221 1222 1223 1224 1225 1226 1227 1228 1229 1230 1231 1232 1233 1234 1235 1236 1237 1238 1239 1240 1241 1242 1243 1244 1245 1246 1247 1248 1249 1250 1251 1252 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1267 1268 1269 1270 1271 1272 1273 1274 1275 1276 1277 1278 1279 1280 1281 1282 1283 1284 1285 1286 1287 1288 1289 1290 1291 1292 1293 1294 1295 1296 1297 1298 1299 1300 1301 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1312 1313 1314 1315 1316 1317 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331 1332 1333 1334 1335 1336 1337 1338 1339 1340 1341 1342 1343 1344 1345 1346 1347 1348 1349 1350 1351 1352 1353 1354 1355 1356 1357 1358 1359 1360 1361 1362 1363 1364 1365 1366 1367 1368 1369 1370 1371 1372 1373 1374 1375 1376 1377 1378 1379 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 1390 1391 1392 1393 1394 1395 1396 1397 1398 1399 1400 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410 1411 1412 1413 1414 1415 1416 1417 1418 1419 1420 1421 1422 1423 1424 1425 1426 1427 1428 1429 1430 1431 1432 1433 1434 1435 1436 1437 1438 1439 1440 1441 1442 1443 1444 1445 1446 1447 1448 1449 1450 1451 1452 1453 1454 1455 1456 1457 1458 1459 1460 1461 1462 1463 1464 1465 1466 1467 1468 1469 1470 1471 1472 1473 1474 1475 1476 1477 1478 1479 1480 1481 1482 1483 1484 1485 1486 1487 1488 1489 1490 1491 1492 1493 1494 1495 1496 1497 1498 1499 1500 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 1522 1523 1524 1525 1526 1527 1528 1529 1530 1531 1532 1533 1534 1535 1536 1537 1538 1539 1540 1541 1542 1543 1544 1545 1546 1547 1548 1549 1550 1551 1552 1553 1554 1555 1556 1557 1558 1559 1560 1561 1562 1563 1564 1565 1566 1567 1568 1569 1570 1571 1572 1573 1574 1575 1576 1577 1578 1579 1580 1581 1582 1583 1584 1585 1586 1587 1588 1589 1590 1591 1592 1593 1594 1595 1596 1597 1598 1599 1600 1601 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 1613 1614 1615 1616 1617 1618 1619 1620 1621 1622 1623 1624 1625 1626 1627 1628 1629 1630 1631 1632 1633 1634 1635 1636 1637 1638 1639 1640 1641 1642 1643 1644 1645 1646 1647 1648 1649 1650 1651 1652 1653 1654 1655 1656 1657 1658 1659 1660 1661 1662 1663 1664 1665 1666 1667 1668 1669 1670 1671 1672 1673 1674 1675 1676 1677 1678 1679 1680 1681 1682 1683 1684 1685 1686 1687 1688 1689 1690 1691 1692 1693 1694 1695 1696 1697 1698 1699 1700 1701 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 1724 1725 1726 1727 1728 1729 1730 1731 1732 1733 1734 1735 1736 1737 1738 1739 1740 1741 1742 1743 1744 1745 1746 1747 1748 1749 1750 1751 1752 1753 1754 1755 1756 1757 1758 1759 1760 1761 1762 1763 1764 1765 1766 1767 1768 1769 1770 1771 1772 1773 1774 1775 1776 1777 1778 1779 1780 1781 1782 1783 1784 1785 1786 1787 1788 1789 1790 1791 1792 1793 1794 1795 1796 1797 1798 1799 1800 1801 1802 1803 1804 1805 1806 1807 1808 1809 1810 1811 1812 1813 1814 1815 1816 1817 1818 1819 1820 1821 1822 1823 1824 1825 1826 1827 1828 1829 1830 1831 1832 1833 1834 1835 1836 1837 1838 1839 1840 1841 1842 1843 1844 1845 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1868 1869 1870 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 1881 1882 1883 1884 1885 1886 1887 1888 1889 1890 1891 1892 1893 1894 1895 1896 1897 1898 1899 1900 | <!doctype html>
<html lang="ko">
<head>
<meta charset="utf-8">
<meta name="viewport" content="width=device-width,initial-scale=1">
<title>Open Discovery Challenge #1 Malaria</title>
<!-- An explicit <head> is not optional here: the platform injects its own tags into the
document, and with no head to receive them they land ahead of the doctype, which
drops the whole page into quirks mode. -->
<style>
:root{
--bg:#f6f8fc; --panel:#ffffff; --line:#e3e9f2; --ink:#131a26; --muted:#65748c;
--accent:#0f7b6c; --accent-soft:#e6f5f2; --anchor:#b4740a; --anchor-soft:#fdf4e3;
--bad:#b3261e; --bar:#0f7b6c; --bar-bg:#eef2f8;
--shadow:0 1px 2px rgba(19,26,38,.05),0 8px 24px rgba(19,26,38,.06);
}
*{box-sizing:border-box}
html,body{margin:0;padding:0}
body{background:var(--bg);color:var(--ink);
font:15px/1.6 -apple-system,"Segoe UI",Roboto,"Malgun Gothic","Apple SD Gothic Neo",sans-serif;
-webkit-font-smoothing:antialiased}
.wrap{max-width:1180px;margin:0 auto;padding:26px 20px 70px}
header{position:relative;background:linear-gradient(135deg,#ffffff 0%,#eef6f4 55%,#e7f0fb 100%);
border:1px solid var(--line);border-radius:16px;padding:26px 28px;box-shadow:var(--shadow)}
.ms{margin:0 0 14px;padding:11px 15px;border-radius:10px;font-size:13.5px;line-height:1.65;
background:linear-gradient(120deg,#f4fbf6 0%,#eef7fb 100%);border:1px solid #cfe6d8;color:#1f4a35}
.ms b{font-weight:800}
.ms .n{font-family:var(--m,monospace);font-weight:850;letter-spacing:-.03em}
#cd{margin:0 0 14px}
#cd .cdlab{display:block;font-size:10.5px;font-weight:700;letter-spacing:2px;
text-transform:uppercase;color:var(--muted);margin-bottom:2px}
#cd .cdval{display:block;font-family:ui-monospace,Menlo,Consolas,monospace;
font-size:38px;font-weight:800;letter-spacing:-1px;color:#0f1b2d;
line-height:1.05;font-variant-numeric:tabular-nums;
/* the digits change every second; without a fixed advance the whole line
jitters as glyph widths swap under it */
font-feature-settings:"tnum" 1}
#cd .cdval .d{color:var(--accent)}
#cd.over .cdval{color:var(--muted)}
@media(max-width:720px){#cd .cdval{font-size:28px}}
.eyebrow{color:var(--accent);font-size:11.5px;font-weight:700;letter-spacing:2.4px;
text-transform:uppercase;margin:0 0 6px}
h1{margin:0;font-size:30px;letter-spacing:-.5px;font-weight:800}
h1 em{font-style:normal;color:var(--accent)}
.concept{margin:12px 0 0;font-size:19px;font-weight:700;letter-spacing:-.2px;
color:#1c2a3d;line-height:1.4;max-width:34ch}
.concept b{color:var(--accent)}
.sub{color:var(--muted);font-size:14px;margin:10px 0 0;max-width:70ch}
.wts{display:flex;flex-wrap:wrap;gap:7px;margin-top:16px}
.wts span{font-size:11.5px;font-weight:600;color:#31465e;background:#fff;
border:1px solid var(--line);border-radius:20px;padding:4px 12px}
.wts b{color:var(--accent)}
#intro{margin:0 0 16px;border-radius:14px;overflow:hidden;border:1px solid var(--line);
background:#0d1420;line-height:0;box-shadow:var(--shadow)}
#intro:empty{display:none;margin:0;border:0}
#intro video{width:100%;height:auto;display:block}
#intro .credit{line-height:1.5;font-size:11px;color:#8ea3c0;background:#0d1420;
padding:7px 12px;text-align:right}
#seasonbar{display:flex;gap:6px;margin-bottom:14px}
.pager{display:flex;align-items:center;justify-content:center;gap:6px;
flex-wrap:wrap;padding:14px 4px 2px;font-size:13px}
.pager button{border:1px solid var(--line);background:#fff;color:var(--muted);
border-radius:8px;padding:5px 11px;cursor:pointer;font:inherit;min-width:36px}
.pager button:hover:not(:disabled){border-color:var(--accent);color:var(--accent)}
.pager button.on{background:var(--accent);color:#fff;border-color:var(--accent)}
.pager button:disabled{opacity:.4;cursor:default}
.pager .pinfo{color:var(--muted);margin:0 8px}
.pager .gap{color:var(--muted);padding:0 2px}
#seasonbar button{border:1px solid var(--line);background:#fff;color:var(--muted);
font:inherit;font-size:12.5px;font-weight:700;padding:7px 14px;
border-radius:999px;cursor:pointer;display:flex;align-items:center;
gap:7px}
#seasonbar button.on{background:var(--accent);color:#fff;border-color:var(--accent)}
#seasonbar .st{font-size:10px;font-weight:800;letter-spacing:.04em;padding:1px 6px;
border-radius:999px;background:#eef3fa;color:var(--muted)}
#seasonbar button.on .st{background:rgba(255,255,255,.22);color:#fff}
@media(max-width:720px){#seasonbar{flex-wrap:wrap}}
#tally{position:absolute;top:62px;right:22px;display:flex;gap:8px;z-index:5}
#tally .t{background:#fff;border:1px solid var(--line);border-radius:10px;
padding:6px 11px;box-shadow:var(--shadow);text-align:right;line-height:1.15}
#tally .t b{display:block;font-size:16px;font-weight:800;color:#16223a;
font-variant-numeric:tabular-nums}
#tally .t span{font-size:9.5px;color:var(--muted);letter-spacing:.02em}
@media(max-width:860px){#tally{position:static;margin:0 0 12px;justify-content:flex-start}}
#langbar{position:absolute;top:20px;right:22px;display:flex;gap:2px;background:#fff;
border:1px solid var(--line);border-radius:9px;padding:3px;box-shadow:var(--shadow)}
#langbar button{border:0;background:transparent;color:var(--muted);font:inherit;
font-size:12px;font-weight:700;padding:5px 11px;border-radius:6px;cursor:pointer}
#langbar button.on{background:var(--accent);color:#fff}
#langnote{position:absolute;top:56px;right:22px;font-size:10.5px;color:var(--muted)}
.how{margin-top:20px;background:var(--panel);border:1px solid var(--line);
border-radius:16px;padding:20px 22px;box-shadow:var(--shadow)}
.how h2{margin:0 0 6px;font-size:13px;letter-spacing:1.4px;text-transform:uppercase;color:var(--muted)}
.how .why{color:#31465e;font-size:13.5px;margin:0 0 16px;max-width:88ch}
.steps{display:grid;grid-template-columns:repeat(3,1fr);gap:14px}
@media(max-width:820px){.steps{grid-template-columns:1fr}}
.step{position:relative;background:#fbfcfe;border:1px solid var(--line);
border-radius:12px;padding:14px 16px 15px}
.step .n{position:absolute;top:-10px;left:14px;width:24px;height:24px;border-radius:50%;
background:var(--accent);color:#fff;font-size:12px;font-weight:800;
display:flex;align-items:center;justify-content:center;
box-shadow:0 2px 6px rgba(15,123,108,.3)}
.step h3{margin:8px 0 5px;font-size:14px;font-weight:800}
.step p{margin:0;font-size:12.5px;color:var(--muted);line-height:1.65}
.models{display:flex;flex-wrap:wrap;gap:5px;margin-top:9px}
.models span{font-size:10.5px;font-weight:700;color:#31465e;background:#fff;
border:1px solid var(--line);border-radius:6px;padding:2px 7px}
#authbar{position:absolute;top:20px;right:150px;display:flex;align-items:center;gap:8px}
#authbar .u{display:flex;align-items:center;gap:7px;background:#fff;border:1px solid var(--line);
border-radius:9px;padding:4px 10px 4px 5px;box-shadow:var(--shadow);font-size:12.5px;font-weight:700}
#authbar .u img{width:22px;height:22px;border-radius:50%;display:block}
#authbar .u a{color:var(--muted);text-decoration:none;font-weight:600;font-size:11px;margin-left:2px}
.hfbtn{display:inline-flex;align-items:center;gap:7px;background:#111827;color:#fff;
border:0;border-radius:9px;padding:8px 13px;font:inherit;font-size:12.5px;
font-weight:700;cursor:pointer;text-decoration:none;box-shadow:var(--shadow)}
.hfbtn:hover{background:#000}
.gate{margin-top:14px;background:#fff8ea;border:1px solid #f0dfba;border-radius:10px;
padding:12px 13px;font-size:12.5px;color:#7a5a12;line-height:1.6}
.gate .hfbtn{margin-top:9px;width:100%;justify-content:center}
#ov{position:fixed;z-index:50;display:none;width:340px;background:#fff;
border:1px solid var(--line);border-radius:14px;padding:15px 16px;
box-shadow:0 12px 40px rgba(19,26,38,.18)}
#ov h4{margin:0 0 2px;font-size:14px;font-weight:800;letter-spacing:-.2px}
#ov .oid{font-size:11px;color:var(--muted);font-family:ui-monospace,monospace;margin-bottom:10px}
#ov .orow{display:grid;grid-template-columns:60px 1fr 42px;gap:8px;align-items:center;
padding:5px 0;border-top:1px solid #f0f3f8;font-size:11.5px}
#ov .orow:first-of-type{border-top:0}
#ov .oax{color:var(--muted);font-weight:700}
#ov .obar{height:5px;border-radius:3px;background:var(--bar-bg);overflow:hidden}
#ov .obar i{display:block;height:100%;background:var(--bar);border-radius:3px}
#ov .opt{text-align:right;font-weight:800;font-variant-numeric:tabular-nums}
#ov .why{grid-column:2 / -1;color:var(--muted);font-size:10.5px;margin-top:-2px;line-height:1.5}
#ov .osum{margin-top:11px;padding-top:10px;border-top:1px solid var(--line);
font-size:11px;color:#31465e;line-height:1.65}
#ov .osum b{color:var(--accent)}
#ov .ofoot{margin-top:9px;font-size:10px;color:var(--muted);line-height:1.5}
#ov .oflag{margin-top:9px;background:#fdeeec;border-radius:7px;padding:7px 9px;
font-size:10.5px;color:var(--bad);line-height:1.5}
tbody tr{cursor:help}
#tabs{display:flex;gap:6px;margin-top:20px}
#tabs button{border:1px solid var(--line);background:#fff;color:var(--muted);
font:inherit;font-size:13.5px;font-weight:700;padding:10px 20px;border-radius:11px;
cursor:pointer;box-shadow:var(--shadow)}
#tabs button.on{background:var(--accent);color:#fff;border-color:var(--accent)}
.panel{display:none} .panel.on{display:block}
.gsec{margin-top:20px}
.gsec h3{margin:0 0 4px;font-size:16px;font-weight:800;letter-spacing:-.2px}
.gsec .lead{color:var(--muted);font-size:13px;margin:0 0 14px;max-width:82ch;line-height:1.7}
.facts{display:grid;grid-template-columns:repeat(3,1fr);gap:12px}
@media(max-width:820px){.facts{grid-template-columns:1fr}}
.fact{background:#fbfcfe;border:1px solid var(--line);border-radius:11px;padding:13px 15px}
.fact b{display:block;font-size:11px;letter-spacing:.8px;text-transform:uppercase;
color:var(--accent);margin-bottom:5px}
.fact span{font-size:12.5px;color:#31465e;line-height:1.6}
.pcard{border:1px solid var(--line);border-radius:12px;margin-bottom:12px;overflow:hidden}
.phead{display:flex;align-items:center;gap:10px;padding:12px 15px;background:#fbfcfe;
border-bottom:1px solid var(--line)}
.ptag{background:var(--accent);color:#fff;font-size:11px;font-weight:800;
width:24px;height:24px;border-radius:7px;display:flex;align-items:center;
justify-content:center;flex:none}
.phead b{font-size:13.5px} .phead span{font-size:11.5px;color:var(--muted)}
.pcopy{margin-left:auto;background:#111827;color:#fff;border:0;border-radius:8px;
padding:6px 13px;font:inherit;font-size:11.5px;font-weight:700;cursor:pointer}
.pcopy:hover{background:#000}
.pbody{padding:0;margin:0;background:#0f1420;color:#dbe4f0;font-size:11.5px;
line-height:1.75;white-space:pre-wrap;word-break:break-word;
font-family:ui-monospace,Menlo,Consolas,monospace;padding:14px 15px;max-height:290px;
overflow:auto}
.pbody em{color:#f0b429;font-style:normal;font-weight:700}
.eng{display:grid;grid-template-columns:1fr 1fr;gap:14px;margin-top:6px}
@media(max-width:820px){.eng{grid-template-columns:1fr}}
.ecard{background:#fbfcfe;border:1px solid var(--line);border-radius:12px;padding:15px 16px}
.ecard h4{margin:0 0 3px;font-size:14.5px;font-weight:800}
.ecard .role{font-size:11px;letter-spacing:.6px;text-transform:uppercase;
color:var(--accent);font-weight:700;margin-bottom:8px}
.ecard p{margin:0;font-size:12.5px;color:var(--muted);line-height:1.7}
.ecard ul{margin:9px 0 0;padding-left:17px;font-size:12.5px;color:#31465e;line-height:1.75}
.proof{margin-top:14px;background:var(--accent-soft);border:1px solid #c6e6df;
border-radius:11px;padding:14px 16px}
.proof b{color:#0b5c51}
.proof p{margin:0 0 8px;font-size:12.5px;color:#0b5c51;line-height:1.7}
.boards{display:flex;flex-wrap:wrap;gap:5px;margin-top:9px}
.boards span{font-size:10.5px;font-weight:700;background:#fff;border:1px solid #c6e6df;
color:#0b5c51;border-radius:6px;padding:3px 8px;font-family:ui-monospace,monospace}
.fails{width:100%;border-collapse:collapse;font-size:12.5px;margin-top:4px}
.fails th{text-align:left;font-size:11px;padding-bottom:8px}
.fails td{padding:9px 10px 9px 0;border-top:1px solid #f0f3f8;vertical-align:top;text-align:left}
.fails td:first-child{font-weight:700;white-space:nowrap;color:var(--bad);width:200px}
.terms{margin-top:20px;display:grid;grid-template-columns:1fr 1fr;gap:20px}
@media(max-width:900px){.terms{grid-template-columns:1fr}}
.prize{background:linear-gradient(135deg,#fffdf7 0%,#fdf4e3 100%);border-color:#f0dfba}
.prize .amt{font-size:34px;font-weight:900;color:var(--anchor);letter-spacing:-1px;margin:4px 0 2px}
.prize .amt small{font-size:13px;font-weight:700;color:#9a7420;letter-spacing:0}
.prize p{font-size:13px;color:#6b5a36;margin:0 0 9px;line-height:1.7}
.prize .tot{font-size:12.5px;font-weight:700;color:#9a7420;margin:0 0 10px}
.prize .fine{font-size:11.5px;color:#8a7649;border-top:1px solid #f0dfba;padding-top:10px;margin-top:2px}
.own p{font-size:13px;color:#31465e;margin:0 0 9px;line-height:1.7}
.own .warn{background:#fdeeec;border:1px solid #f3d3ce;border-radius:9px;
padding:11px 13px;font-size:12.5px;color:#8e2f27;line-height:1.65;margin-top:4px}
.own .keep{background:var(--accent-soft);border:1px solid #c6e6df;border-radius:9px;
padding:11px 13px;font-size:12.5px;color:#0b5c51;line-height:1.65}
.vis{display:flex;gap:8px;margin-top:6px}
.vis label{flex:1;margin:0;display:flex;gap:8px;align-items:flex-start;cursor:pointer;
background:#fbfcfe;border:1px solid var(--line);border-radius:9px;padding:10px 11px;
font-size:12px;font-weight:600;color:var(--ink);letter-spacing:0;text-transform:none}
.vis label.on{border-color:var(--accent);background:var(--accent-soft)}
.vis input{width:auto;margin:2px 0 0}
.vis span{display:block;font-weight:500;color:var(--muted);font-size:11px;margin-top:2px}
.chart{margin-top:20px}
.mrow{display:grid;grid-template-columns:150px 1fr 132px;gap:12px;align-items:center;
padding:9px 0;border-bottom:1px solid #f0f3f8}
.mrow:last-child{border-bottom:0}
.mname{font-size:13px;font-weight:700;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.mname span{display:block;font-size:10.5px;color:var(--muted);font-weight:600}
.mtrack{position:relative;height:22px;background:var(--bar-bg);border-radius:6px;overflow:visible}
.mtrack .best{position:absolute;left:0;top:0;bottom:0;background:linear-gradient(90deg,#0f7b6c,#2aa694);
border-radius:6px}
.mtrack .mean{position:absolute;top:-3px;bottom:-3px;width:2px;background:#123;opacity:.55}
.mmerge{font-size:9.5px;color:var(--accent);vertical-align:super;font-weight:800}
.mtrack .lab{position:absolute;right:7px;top:0;line-height:22px;font-size:11.5px;
font-variant-numeric:tabular-nums;
font-weight:800;color:#fff;text-shadow:0 1px 2px rgba(0,0,0,.25)}
.muse{display:flex;align-items:center;gap:7px;justify-content:flex-end}
.muse .ub{height:8px;border-radius:4px;background:#9db4d6;min-width:3px}
.muse .un{font-size:11.5px;color:var(--muted);font-weight:700;white-space:nowrap}
.legend{display:flex;gap:14px;flex-wrap:wrap;margin-top:12px;font-size:11px;color:var(--muted)}
.legend i{display:inline-block;width:10px;height:10px;border-radius:3px;margin-right:5px;vertical-align:-1px}
.grid{display:grid;grid-template-columns:1fr 348px;gap:20px;align-items:start;margin-top:20px}
/* A grid item defaults to min-width:auto, so the 1fr column refused to shrink below
the table's min-width and pushed the submission card off-screen. */
.grid > *{min-width:0}
@media(max-width:960px){.grid{grid-template-columns:1fr}#langbar{position:static;margin-bottom:14px;width:max-content}#langnote{position:static;margin-bottom:8px}}
.card{background:var(--panel);border:1px solid var(--line);border-radius:16px;
padding:18px 20px;box-shadow:var(--shadow)}
.card h2{margin:0 0 4px;font-size:13px;letter-spacing:1.4px;text-transform:uppercase;color:var(--muted)}
.cnt{float:right;font-size:11.5px;color:var(--muted);letter-spacing:0}
.scroll{overflow-x:auto;margin-top:12px}
table{width:100%;border-collapse:collapse;font-size:13.5px;min-width:760px}
th{color:var(--muted);font-weight:700;font-size:11px;letter-spacing:.5px;
text-transform:uppercase;padding:0 9px 10px;border-bottom:2px solid var(--line);
text-align:right;cursor:pointer;user-select:none;white-space:nowrap}
th:nth-child(-n+3){text-align:left}
th:hover{color:var(--accent)}
th .ar{opacity:.32;margin-left:3px;font-size:9px}
th.sorted{color:var(--accent)} th.sorted .ar{opacity:1}
td{padding:11px 9px;border-bottom:1px solid #f0f3f8;text-align:right;
font-variant-numeric:tabular-nums}
td:nth-child(-n+3){text-align:left}
tbody tr:hover{background:#fbfcfe}
tr.anchor{background:var(--anchor-soft)}
tr.anchor:hover{background:#fbf0dc}
.sd{color:#8a8f98;font-size:10.5px;margin-left:3px;font-weight:500}
.tag.w{background:#fff4e5;color:#9a5b00;border:1px solid #f0d9b5}
tr.tier2{opacity:.62}
.rk{width:58px;color:var(--muted);font-weight:700;white-space:nowrap}
.rk.top{color:var(--accent);font-size:15px}
.tot{font-variant-numeric:tabular-nums}
.rk .rkscore{display:block;margin-top:2px;font-size:10.5px;font-weight:800;
font-variant-numeric:tabular-nums;
color:var(--ink);letter-spacing:0}
.cid{font-family:ui-monospace,Menlo,Consolas,monospace;font-size:12.5px;font-weight:600}
.skel{color:#93a1b5;font-size:11px;font-family:ui-monospace,monospace}
.smiwrap{display:flex;align-items:center;gap:6px;max-width:250px}
.smi2{color:#1c2a3d;font-size:12px;font-weight:600;
font-family:ui-monospace,Menlo,Consolas,monospace;
overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.cp{flex:none;border:1px solid var(--line);background:#fff;border-radius:6px;
width:22px;height:22px;line-height:1;cursor:pointer;color:var(--muted);
font-size:11px;padding:0}
.cp:hover{border-color:var(--accent);color:var(--accent);background:var(--accent-soft)}
.cp.done{border-color:var(--accent);color:#fff;background:var(--accent)}
.lock{color:#93a1b5;font-size:10.5px;margin-top:1px;display:block}
#ov .osmi{margin-top:10px;padding:9px 10px;background:#f6f8fc;border:1px solid var(--line);
border-radius:8px;font-family:ui-monospace,Menlo,monospace;font-size:10.5px;
color:#31465e;line-height:1.5;word-break:break-all;position:relative}
#ov .osmi .cp{position:absolute;top:6px;right:6px}
#ov .osmi .d3{position:absolute;top:6px;right:32px}
.d3{flex:none;border:1px solid var(--line);background:#fff;border-radius:6px;
height:22px;padding:0 6px;line-height:1;cursor:pointer;color:var(--muted);
font-size:10px;font-weight:700;letter-spacing:.02em}
.d3:hover{border-color:var(--accent);color:var(--accent);background:var(--accent-soft)}
/* the viewer is a modal, not a panel: a molecule you are turning over deserves the
whole window, and the table underneath would only compete for the drag */
#m3{position:fixed;inset:0;z-index:120;display:none;background:rgba(16,23,34,.55);
backdrop-filter:blur(3px)}
#m3.on{display:flex;align-items:center;justify-content:center}
#m3 .box{background:#fff;border-radius:16px;width:min(720px,94vw);
box-shadow:0 24px 70px rgba(12,18,28,.35);overflow:hidden}
#m3 .hd{display:flex;align-items:center;gap:10px;padding:12px 14px;
border-bottom:1px solid var(--line)}
#m3 .hd b{font-size:13px;color:#16223a}
#m3 .hd .f{font-family:ui-monospace,Menlo,monospace;font-size:11px;color:var(--muted)}
#m3 .hd .x{margin-left:auto;border:0;background:none;font-size:20px;line-height:1;
cursor:pointer;color:var(--muted);padding:0 4px}
#m3 .stage{position:relative;height:min(430px,52vh);background:#0d1420}
#m3 .stage canvas{display:block}
#m3 .msg{position:absolute;inset:0;display:flex;align-items:center;justify-content:center;
color:#93a6c0;font-size:12px}
#m3 .ft{display:flex;align-items:center;gap:8px;padding:10px 14px;flex-wrap:wrap}
#m3 .ft .sm{font-family:ui-monospace,Menlo,monospace;font-size:10.5px;color:#4a5d78;
word-break:break-all;flex:1;min-width:0}
#m3 .ft button{border:1px solid var(--line);background:#fff;border-radius:7px;
padding:5px 10px;font-size:11px;cursor:pointer;color:#33465f}
#m3 .ft button:hover{border-color:var(--accent);color:var(--accent)}
#m3 .ft button.on{border-color:var(--accent);background:var(--accent);color:#fff}
.who{color:var(--muted);font-size:12.5px}
.hf-user{color:var(--accent);font-weight:700;text-decoration:none;white-space:nowrap}
.hf-user:hover{text-decoration:underline}
/* Long model identifiers wrapped onto four lines and made every row three times
taller than it needed to be. Truncate; the full value is on the tooltip. */
td:nth-child(3), td:nth-child(4){max-width:150px}
td:nth-child(3) > *, td:nth-child(4) > *{display:block;max-width:150px;
overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
td:nth-child(2){max-width:300px}
.tag{display:inline-block;font-size:9.5px;font-weight:800;letter-spacing:.7px;
padding:2px 7px;border-radius:5px;margin-left:6px;vertical-align:1px}
.tag.a{background:#f6e2ba;color:var(--anchor)}
.tag.r{background:#f7ded9;color:var(--bad)}
.tot{font-weight:800;font-size:15.5px}
.barwrap{display:flex;align-items:center;gap:8px;justify-content:flex-end}
.bar{width:52px;height:6px;border-radius:4px;background:var(--bar-bg);overflow:hidden;flex:none}
.bar i{display:block;height:100%;background:var(--bar);border-radius:4px}
tr.anchor .bar i{background:var(--anchor)}
label{display:block;font-size:11.5px;font-weight:700;color:var(--muted);
margin:14px 0 5px;letter-spacing:.3px}
input,textarea{width:100%;background:#fbfcfe;border:1px solid var(--line);border-radius:9px;
color:var(--ink);padding:10px 12px;font:inherit;font-size:13.5px}
input:focus,textarea:focus{outline:0;border-color:var(--accent);background:#fff;
box-shadow:0 0 0 3px var(--accent-soft)}
textarea{resize:vertical;min-height:58px}
button.go{width:100%;margin-top:18px;background:var(--accent);color:#fff;border:0;
border-radius:10px;padding:12px;font:inherit;font-weight:800;cursor:pointer;
box-shadow:0 4px 12px rgba(15,123,108,.24)}
button.go:hover{background:#0c6558} button.go:disabled{opacity:.5;cursor:default;box-shadow:none}
.msg{margin-top:13px;font-size:12.5px;padding:11px 13px;border-radius:9px;display:none;line-height:1.55}
.msg.ok{display:block;background:var(--accent-soft);color:#0b5c51;border:1px solid #c6e6df}
.msg.err{display:block;background:#fdeeec;color:var(--bad);border:1px solid #f3d3ce}
.note{color:var(--muted);font-size:11.5px;line-height:1.7;margin-top:16px;
border-top:1px solid var(--line);padding-top:13px}
.note b{color:#31465e}
.xlink{display:inline-flex;align-items:center;gap:7px;border:1px solid var(--line);
background:var(--card);border-radius:9px;padding:6px 12px;font-size:12.5px;
color:var(--muted);text-decoration:none;margin:8px 0 0}
.xlink:hover{border-color:var(--accent);color:var(--accent)}
.xlink b{color:var(--ink);font-weight:600}
.xlink em{font-style:normal;opacity:.75}
</style>
</head>
<body>
<div id="ov"></div>
<div id="m3"><div class="box">
<div class="hd"><b id="m3f"></b><span class="f" id="m3w"></span>
<button class="x" id="m3x" aria-label="close">ร</button></div>
<div class="stage"><div id="m3v" style="width:100%;height:100%;position:relative"></div>
<div class="msg" id="m3m"></div></div>
<div class="ft"><span class="sm" id="m3s"></span>
<button id="m3st" class="on" data-s="stick">Stick</button>
<button id="m3sp" data-s="sphere">Space-fill</button>
<button id="m3rt" class="on" title="spin">โป</button></div>
</div></div>
<div class="wrap">
<header>
<div id="langbar">
<button data-lang="ko">ํ๊ตญ์ด</button><button data-lang="en">English</button>
</div>
<div id="authbar"></div>
<div id="langnote"></div>
<div id="tally"></div>
<div id="seasonbar"></div>
<a class="xlink" id="xlink" href="https://huggingface.co/spaces/FINAL-Bench/open-materials-challenge" target="_blank" rel="noopener"></a>
<a class="xlink" id="xlink2" href="https://huggingface.co/spaces/FINAL-Bench/leadboard" target="_blank" rel="noopener"></a>
<div id="milestone" class="ms" hidden></div>
<div id="cd"><span class="cdlab" id="cdlab"></span><span class="cdval" id="cdval"> </span></div>
<p class="eyebrow">Open Discovery Challenge</p>
<h1 id="seasonhead">#1 <em data-i18n="topic">Malaria</em></h1>
<p class="concept" id="concept"></p>
<p class="sub" data-i18n="tagline"></p>
<div class="wts" id="wts"></div>
</header>
<section class="how">
<h2 data-i18n="how_h">How it works</h2>
<p class="why" id="why"></p>
<div class="steps">
<div class="step"><span class="n">1</span>
<h3 data-i18n="s1_h"></h3><p data-i18n="s1_p"></p>
<div class="models">
<span>OpenAI</span><span>Claude</span><span>Gemini</span>
<span>Qwen</span><span>KIMI</span><span>DeepSeek</span><span>โฆ</span>
</div>
</div>
<div class="step"><span class="n">2</span>
<h3 data-i18n="s2_h"></h3><p data-i18n="s2_p"></p></div>
<div class="step"><span class="n">3</span>
<h3 data-i18n="s3_h"></h3><p data-i18n="s3_p"></p></div>
</div>
</section>
<div id="tabs">
<button data-panel="board" class="on" data-i18n="tab_board">Leaderboard</button>
<button data-panel="models" data-i18n="tab_models">Model standings</button>
<button data-panel="guide" data-i18n="tab_guide">Entrant guide</button>
</div>
<div class="panel on" id="p-board">
<section class="terms">
<div class="card prize">
<h2 data-i18n="prize_h">Prize</h2>
<div class="amt" id="prize_amt">$1,000 <small data-i18n="prize_unit">USD</small></div>
<div class="tot" id="prize_total"></div>
<p id="prize_body"></p>
<div class="fine" id="prize_fine"></div>
</div>
<div class="card own">
<h2 data-i18n="own_h">Your molecule stays yours</h2>
<div class="keep" id="own_keep"></div>
<p id="own_body" style="margin-top:10px"></p>
<div class="warn" id="own_warn"></div>
</div>
</section>
<div class="grid">
<div class="card">
<h2><span data-i18n="board">Leaderboard</span><span class="cnt" id="counts"></span></h2>
<div class="scroll">
<table>
<thead><tr id="head"></tr></thead>
<tbody id="rows"></tbody>
</table>
</div>
<div class="pager" id="pager"></div>
<div class="note" id="boardnote"></div>
</div>
<div class="card">
<h2 data-i18n="submit">Submit</h2>
<label data-i18n="l_struct"></label>
<input id="structure" placeholder="CC1=NC2=NC(=NN2C(=C1)N...">
<label data-i18n="l_name"></label>
<input id="display_name">
<label data-i18n="l_model"></label>
<input id="model_name" placeholder="anthropic/claude-โฆ, Qwen/โฆ">
<label data-i18n="l_why"></label>
<textarea id="rationale"></textarea>
<label data-i18n="l_vis"></label>
<div class="vis">
<label class="on" id="vis_priv"><input type="radio" name="vis" value="private" checked>
<b data-i18n="vis_priv"></b></label>
<label id="vis_pub"><input type="radio" name="vis" value="public">
<b data-i18n="vis_pub"></b></label>
</div>
<button class="go" id="go" data-i18n="btn"></button>
<div class="gate" id="gate" style="display:none"></div>
<div class="msg" id="msg"></div>
<div class="note" id="formnote"></div>
</div>
</div>
</div>
<div class="panel" id="p-models">
<section class="card chart">
<h2><span data-i18n="chart_h">Model standings</span><span class="cnt" id="mcounts"></span></h2>
<p class="who" id="chart_sub" style="margin:2px 0 10px"></p>
<div id="models"></div>
<div class="legend" id="legend"></div>
</section>
</div>
<div class="panel" id="p-guide">
<!-- ์์ฆ ์๊ฐ ์์. ์ฒซ ํ๋ฉด(์์ํ)์ด ์๋๋ผ ๊ฐ์ด๋ ํญ์ ๋๋ค - ๋ณด๋ฌ ์จ
์ฌ๋์ ์์๋ฅผ ๋ณด๋ฌ ์ค์ง ์์์ ๋ณด๋ฌ ์ค์ง ์๋๋ค. ๊ฐ์ด๋๋ฅผ ํผ์น ์ฌ๋์๊ฒ๋
๋งฅ๋ฝ์ด ๋๋ฏ๋ก ๊ฑฐ๊ธฐ์ ๊ฐ์ ํ๋ค. -->
<div id="intro"></div>
<section class="card gsec">
<h3 data-i18n="g1_h"></h3>
<p class="lead" id="g1_lead"></p>
<div class="facts">
<div class="fact"><b data-i18n="g1_a_t"></b><span data-i18n="g1_a"></span></div>
<div class="fact"><b data-i18n="g1_b_t"></b><span data-i18n="g1_b"></span></div>
<div class="fact"><b data-i18n="g1_c_t"></b><span data-i18n="g1_c"></span></div>
</div>
</section>
<section class="card gsec">
<h3 data-i18n="g2_h"></h3>
<p class="lead" id="g2_lead"></p>
<div id="prompts"></div>
</section>
<section class="card gsec">
<h3 data-i18n="ge_h"></h3>
<p class="lead" id="ge_lead"></p>
<div class="eng">
<div class="ecard">
<div class="role" data-i18n="ge_p_role"></div>
<h4>PharmaOS</h4>
<p data-i18n="ge_p_body"></p>
<ul id="ge_p_list"></ul>
</div>
<div class="ecard">
<div class="role" data-i18n="ge_c_role"></div>
<h4>CellOS</h4>
<p data-i18n="ge_c_body"></p>
<ul id="ge_c_list"></ul>
</div>
</div>
<div class="proof">
<p id="ge_proof"></p>
<div class="boards" id="ge_boards"></div>
<p id="ge_caveat" style="margin-top:10px;font-size:11.5px;opacity:.85"></p>
</div>
</section>
<section class="card gsec">
<h3 data-i18n="g3_h"></h3>
<p class="lead" id="g3_lead"></p>
<table class="fails"><tbody id="fails"></tbody></table>
</section>
<section class="card gsec">
<h3 data-i18n="g4_h"></h3>
<p class="lead" id="g4_lead"></p>
</section>
</div>
</div>
<script>
const T = {
ko:{
xlink:`๐ <b>Open Materials Challenge</b> <em>โ ์ ๊ณ ์ฒด ๋ฐฐํฐ๋ฆฌ ์ ์์ฌ๋ฅผ ์ฐพ๋ ์๋งค ๋ํ</em> โ`,
xlink2:`๐ฏ <b>LEADBOARD</b> <em>โ ์ ์ฝ ์์ธก ๋๊ตฌ๋ฅผ ๋ถ์ผ๋ณ๋ก ์ฌ๋ ์ํ๋</em> โ`,
topic:"๋ง๋ผ๋ฆฌ์", board:"์์ํ", submit:"์ ์ถ", btn:"์ ์ถํ๊ธฐ",
concept:"<b>AI๊ฐ ๋ฐ๊ฒฌํ ๋ง๋ผ๋ฆฌ์ ์ ์ฝ ํ๋ณด ๋ฌผ์ง</b>์ ๊ฒ์ฆ ๋ฐ ํ๊ฐ",
tagline:"์ด๋ค AI๋ก ์ฐพ์๋ธ ํ๋ณด๋ , ๊ฐ์ ๊ธฐ์ค์ผ๋ก ๊ณ์ฐ ๊ฒ์ฆํ๊ณ ์ ์๋ฅผ ๋งค๊น๋๋ค. ํ์ ์ ๋ง๋ผ๋ฆฌ์ ์์ถฉ์ด ์์กดํ๋ ํจ์ PfDHODH์ด๋ฉฐ, ์ฌ๋์ ๊ฐ์ ํจ์(DHODH)๋ ๊ฑด๋๋ฆฌ์ง ์์์ผ ํฉ๋๋ค.",
how_h:"์ฐธ์ฌ ๋ฐฉ๋ฒ",
why:"<b>๋งค๋
์ฝ 59๋ง 7์ฒ ๋ช
์ด ๋ง๋ผ๋ฆฌ์๋ก ์ฃฝ์ต๋๋ค. ๊ทธ์ค 4๋ถ์ 3์ด ๋ค์ฏ ์ด์ด ๋๊ธฐ ์ ์ ์์ด๋ค์
๋๋ค</b>(WHO ์ธ๊ณ ๋ง๋ผ๋ฆฌ์ ๋ณด๊ณ ์ 2024, 2023๋
์ถ์ ). ์ฝ์ด ์์ด์๊ฐ ์๋๋๋ค. ํ์๊ฐ ๊ฐ๋ํด์ ์ฝ์ ๋ง๋ค ์ด์ ๊ฐ ์์ฅ์ ์๊ธฐ ๋๋ฌธ์
๋๋ค. ๋ฐ๋ก ๊ทธ๋์, ์ด์ต์ด ์๋๋ผ ๋ป์ผ๋ก ์์ง์ด๋ ์ฌ๋๋ค์ด ์ค์ ๋ก ์ฐจ์ด๋ฅผ ๋ง๋ค ์ ์๋ ์๋ฆฌ์
๋๋ค.<br><br>AI๋ ์ด๋ฏธ ์ ์ฝ ํ๋ณด๋ฅผ ์์๋ด๊ณ ์์ต๋๋ค. ๋งํ ๊ณณ์ ๋ฐ๊ฒฌ์ด ์๋๋ผ <b>๊ทธ ํ๋ณด๊ฐ ์ ๋ง ์ธ ๋งํ์ง ๊ฐ๋ ค๋ผ ๊ฒ์ฆ ์๋จ</b>์
๋๋ค. ๋ชจ๋ธ์ ๊ทธ๋ด๋ฏํ ๋ถ์๋ฅผ ์ผ๋ง๋ ์ง ๊ทธ๋ ค๋ด์ง๋ง, ๊ทธ๊ฒ์ด ๊ธฐ์์ถฉ์ ์ฃฝ์ด๋์งยท์ฌ๋์๊ฒ ํด๋ก์ด์งยท๋ง๋ค ์๋ ์๋์ง๋ ๋ตํ์ง ๋ชปํฉ๋๋ค. ์ด ์ฑ๋ฆฐ์ง๋ ๊ทธ ๊ฒ์ฆ๊ธฐ๋ฅผ ๊ณต๊ฐํฉ๋๋ค โ <b>AI๊ฐ ๋ฐ๊ฒฌํ ํ๋ณด๋ฅผ ๋ฐ์, ๊ฐ์ ์ฃ๋๋ก ๊ณ์ฐ ๊ฒ์ฆํ๊ณ ์์๋ฅผ ๋งค๊น๋๋ค.</b>",
s1_h:"1. ์ํ๋ AI๋ก ํ๋ณด๋ฅผ ์ค๊ณํฉ๋๋ค",
s1_p:"OpenAI ยท Claude ยท Gemini ยท Qwen ยท KIMI ยท DeepSeek ๋ฑ ์ด๋ค ๋ชจ๋ธ์ด๋ , ์ด๋ค ํ๋ค์ค๋ ์์ ์
๋๋ค. ์ง์ ์ค๊ณํด๋ ๋ฉ๋๋ค. ๋ง๋ผ๋ฆฌ์ ์์ถฉ ํจ์ PfDHODH๋ฅผ ๋ง์ ์ ๋ถ์๋ฅผ ์ฐพ์ผ์ธ์.",
s2_h:"2. ๋ถ์ ๊ตฌ์กฐ์์ ์ ์ถํฉ๋๋ค",
s2_p:"SMILES ๋๋ InChI๋ก ์
๋ ฅํฉ๋๋ค. ์ ์ถ ์ฆ์ ๊ตฌ์กฐ ๊ฒ์ฌ(๋ฐ์์ฑยทPAINSยท์ค๋ณต ๋ฑ)๋ฅผ ๊ฑฐ์นฉ๋๋ค. ๋ถ์์์ ์ด์ฑ์ง์ฒด๊ฐ ๋๋ฌด ๋ง์ ๋ฐ์ง ์์ต๋๋ค.",
s3_h:"3. ์๋ ์ฑ์ ํ ์์๊ฐ ๋งค๊ฒจ์ง๋๋ค",
s3_p:"๋น๋๋ํํธ PharmaOS์ CellOS๊ฐ ์ฝํจยทํ์ ๊ฒฐํฉยท์ ํ์ฑยท๋
์ฑยท์ ๊ท์ฑยทํฉ์ฑ ๋์ด๋๋ฅผ ๊ณ์ฐํด 100์ ๋ง์ ์ผ๋ก ์ฑ์ ํ๊ณ , ๊ณ ๋์ ์์ผ๋ก ์ค์ ์ธ์๋๋ค. ๊ธฐ์ค๋ฌผ์ง์ด ํจ๊ป ํ์๋์ด ์๊ธฐ ์ ์์ ์๋ฏธ๋ฅผ ๋ฐ๋ก ํ์ธํ ์ ์์ต๋๋ค.",
ov_axes:{activity:"์ฝํจ",binding:"๊ฒฐํฉ",selectivity:"์ ํ์ฑ",admet:"ADMET",novelty:"์ ๊ท์ฑ",synthesis:"ํฉ์ฑ"},
ov_why:{
activity:d=>`์ ์ธํฌ ์์ธก pAct(ํํ) ${d.pAct_q10 ?? "โ"}`,
binding:d=>`pIC50 ${d.pIC50 ?? "โ"} ยท ๋ฆฌ๊ฐ๋ํจ์จ ${d.LE ?? "โ"}`,
selectivity:d=>`์ฌ๋ ๋๋น ${d.fold ?? "โ"}๋ฐฐ ยท ํ์ ๊ฒฐํฉ ${d.target_engagement ?? "โ"}`,
admet:d=>`๋ฐ๋์ง์ฑ ๊ธฐํํ๊ท ${d.geometric_mean ?? "โ"}`,
novelty:d=>`๊ธฐ์กด ๋ฌผ์ง๊ณผ ์ต๋ ์ ์ฌ๋ ${d.max_tanimoto ?? "โ"}`,
synthesis:d=>`ํฉ์ฑ๋์ด๋ SA ${d.sa_score ?? "โ"} (1 ์ฌ์ ~ 10 ์ด๋ ค์)`,
},
ov_pred:"์์ธก์น", ov_pf:"๋ง๋ผ๋ฆฌ์ ํจ์", ov_hs:"์ฌ๋ ํจ์", ov_sel:"์ ํ๋",
private_note:"์ ์ถ์๊ฐ ๋น๊ณต๊ฐ๋ฅผ ์ ํํ์ต๋๋ค", copy_smiles:"๋ถ์์ ๋ณต์ฌ",
intro_credit:"์์ ์ ์ํด์ฃผ์ ์นด์นด์คํก @๋ฆฌ์นด ๋์๊ฒ ๊ฐ์ฌ๋๋ฆฝ๋๋ค.",
tally_label:"๋์ ์ ์ถ", daily_cap:"๊ณ์ ๋น ํ๋ฃจ 30๊ฑด๊น์ง ์ ์ถํ ์ ์์ต๋๋ค (ํ๊ตญ์๊ฐ ์์ ์ด๊ธฐํ).",
season_soon:"์ค๋น์ค", season_notopen:"์ด ์์ฆ์ ์์ง ์ ์๋ฅผ ๋ฐ์ง ์์ต๋๋ค. ์ฑ์ ๊ธฐ ๊ฒ์ฆ์ด ๋๋๋ฉด ๊ณต์ง์ ํจ๊ป ์ฝ๋๋ค.",
cd_label:"์์ฆ #1 ๋ง๊ฐ๊น์ง", cd_day:"์ผ", cd_over_label:"์์ฆ #1 ๋ง๊ฐ",
cd_over:"๋ง๊ฐ๋์์ต๋๋ค", view_3d:"3D ์
์ฒด ๊ตฌ์กฐ๋ก ๋ณด๊ธฐ",
v3_loading:"์
์ฒด ๊ตฌ์กฐ ์์ฑ ์ค\u2026", v3_atoms:"์์",
v3_failed:"์
์ฒด ๊ตฌ์กฐ๋ฅผ ๋ง๋ค์ง ๋ชปํ์ต๋๋ค",
private_full:"์ ์ถ์๊ฐ ๋น๊ณต๊ฐ๋ฅผ ์ ํํ์ต๋๋ค. ํ๋ณด ID์ ๊ณจ๊ฒฉ ํด์๋ก๋ง ์๋ณ๋ฉ๋๋ค.",
reasons:{
parse: r=>"๊ตฌ์กฐ๋ฅผ ํด์ํ ์ ์์ต๋๋ค (SMILES ๋๋ InChI๋ก ์ ์ถํ์ธ์)",
covalent: r=>`๊ณต์ ๊ฒฐํฉ warhead ๊ฒ์ถ (${r.arg}) โ Season 1์ ๋น๊ณต์ ํธ๋์
๋๋ค`,
mw: r=>`๋ถ์๋ ${r.arg} > ${r.limit}`,
heavy: r=>`๋ฌด๊ฑฐ์ด ์์ ${r.arg} > ${r.limit}`,
pains: r=>`PAINS ๊ตฌ์กฐ (${r.arg})`,
duplicate: r=>"์ด๋ฏธ ์ ์ถ๋ ๊ตฌ์กฐ์
๋๋ค",
ames: r=>`๋ณ์ด์์ฑ(Ames) ${r.arg} > ${r.limit}`,
solubility: r=>`๊ทน๋จ์ ๋ถ์ฉ์ฑ (logS ${r.arg} < ${r.limit})`,
},
ov_none:"์ฑ์ ๊ทผ๊ฑฐ๊ฐ ๊ธฐ๋ก๋์ง ์์์ต๋๋ค.",
ov_foot:"๋ชจ๋ ๊ณ์ฐ ์์ธก๊ฐ์
๋๋ค. ์ค์ธก์ด ์๋๋ฉฐ ์ค์ ํจ๋ฅยท์์ ์ฑ์ ๋ปํ์ง ์์ต๋๋ค.",
tab_board:"์์ํ",tab_models:"๋ชจ๋ธ ์ฑ๊ณผ", tab_guide:"์ฐธ์ฌ ๊ฐ์ด๋",
ge_h:"๋ฌด์์ด ์ฑ์ ํ๋๊ฐ",
ge_lead:"์ ์ถ๋ ๋ถ์๋ VIDRAFT์ ๋ ์์คํ
์ด ํจ๊ป ํ๊ฐํฉ๋๋ค. ํ๋๋ ๋ถ์๊ฐ ํ์ ์ ์ด๋ป๊ฒ ์์ฉํ๋์ง๋ฅผ ๋ณด๊ณ , ๋ค๋ฅธ ํ๋๋ ๊ทธ๊ฒ์ด ์ด์ ์๋ ์ธํฌ์ ๋ชธ์์ ๋ฌด์์ ๋ปํ๋์ง๋ฅผ ๋ด
๋๋ค.",
ge_p_role:"๋ถ์ ยท ํ์ ", ge_c_role:"์ธํฌ ยท ๊ฐ์ฒด",
ge_p_body:"๋ถ์๊ฐ ํ์ ๋จ๋ฐฑ์ง์ ์ค์ ๋ก ๊ฒฐํฉํ๋์ง, ์ผ๋ง๋ ์ธ๊ฒ ๋ถ๋์ง, ๊ทธ๋ฆฌ๊ณ ๊ทธ ๊ฒฐํฉ์ด ํฌ๊ธฐ๋ก ์ฐ ๊ฒ์ธ์ง ์ค๊ณ๋ก ์ป์ ๊ฒ์ธ์ง๋ฅผ ํ์ ํฉ๋๋ค.",
ge_p_list:["๋ง๋ผ๋ฆฌ์ ํจ์์ ์ฌ๋ ํจ์์ ๊ฐ๊ฐ ๋ํนํด ๊ฒฐํฉ ์์ธก","๋ถ์ ํฌ๊ธฐ ๋๋น ๊ฒฐํฉ ํจ์จ โ ๋ฌด๊ฒ๊ฒ ๋ง๋ค์ด ์ ์๋ฅผ ์ฌ๋ ๊ฒ์ ์ฐจ๋จ","๊ธฐ์กด ํญ๋ง๋ผ๋ฆฌ์ ํํ๊ณต๊ฐ๊ณผ์ ๊ตฌ์กฐ์ ๊ฑฐ๋ฆฌ","ํฉ์ฑ ์ ๊ทผ์ฑ"],
ge_c_body:"๊ฒฐํฉ๋ง์ผ๋ก๋ ์ฝ์ด ๋์ง ์์ต๋๋ค. ๊ธฐ์์ถฉ์ด ์ค์ ๋ก ์ฃฝ๋์ง, ์ฌ๋์๊ฒ ํด๋กญ์ง ์์์ง, ๋ชธ ์์์ ๊ฒฌ๋๋์ง๋ฅผ ๋ด
๋๋ค.",
ge_c_list:["์ ์ธํฌ ํญ๋ง๋ผ๋ฆฌ์ ํ์ฑ โ ๊ธฐ์์ถฉ์ด ์ฃฝ๋๊ฐ","ํก์ยท๋ถํฌยท๋์ฌยท๋ฐฐ์ค๊ณผ ๋
์ฑ ํ๋กํ์ผ","์ฌ๋ ํจ์ ํํผ โ ๋ฉด์ญ์ต์ ๋ถ์์ฉ ์ฐจ๋จ","๋ถํ์คํ ์์ธก์ ๋ฎ๊ฒ ์ฑ์ โ ํ์ ํ ์ ์๋ ํ๋ณด๊ฐ ์ฐ๋๋จ"],
ge_proof:"<b>์ด ์ฑ์ ์ ์ ๋ฏฟ์ ์ ์๋๊ฐ.</b> ์ฐ๋ฆฌ ์์ธก ๋ชจ๋ธ์ ๊ณต๊ฐ ๋ฒค์น๋งํฌ <b>Polaris Hub์ 16๊ฐ ๋ถ๋ฌธ์์ 1์</b>๋ก ๊ธฐ๋ก๋์ด ์์ต๋๋ค. ํก์ยท๋ถํฌยท๋์ฌยท๋
์ฑยทํจ๋ฅยท์ธ์ฐํํจ์ ์ ํ์ฑ ์ ์์ญ์ ๊ฑธ์ณ ์์ผ๋ฉฐ, ๊ฐ์ฅ ์ต๊ทผ์ <b>MDR1-MDCK ์ ์ถ๋น</b>(2026-08-11, ์๊ด๊ณ์ 0.802 ยท 2์ 0.725)์
๋๋ค. ์๋๊ฐ ๊ทธ 16๊ฐ ๋ถ๋ฌธ์ด๋ฉฐ, Polaris์์ ์ฐ๋ ์ด๋ฆ ๊ทธ๋๋ก ์ ์์ผ๋ ์ง์ ๋์กฐํ์ค ์ ์์ต๋๋ค.",
ge_caveat:"โ ๏ธ 16๊ฐ ๋ถ๋ฌธ์ด ๋ชจ๋ Polaris์ ์ค์ฌํ๋ ๋ฒค์น๋งํฌ์์ ํ์ธํ์ต๋๋ค. ๋ค๋ง Polaris Hub๋ ์์(placement)๋ฅผ ๊ณต๊ฐ API๋ก ์ ๊ณตํ์ง ์์ ๋ฑ์ ์์ฒด๋ ์ธ๋ถ์์ ์๋ ๊ฒ์ฆํ ์ ์์ต๋๋ค.<br>๊ทธ๋ฆฌ๊ณ ์ด ๋ํ์ ์ฑ์ ์ด ์ ์งํ์ง๋ ๋ ๊ฐ๋จํ ํ์ธํ์ค ์ ์์ต๋๋ค โ <b>์น์ธ๋ ์ฝ๊ณผ ํจ๊ณผ ์๋ ๋ฌผ์ง์ ์์ํ์ ํจ๊ป ์ฌ๋ ค๋์์ต๋๋ค.</b> ์์ ํ๋ณด๊ฐ ์๋จ์, ์นดํ์ธ๊ณผ ์ด๋ถํ๋กํ์ด ๋ฐ๋ฅ์ ์๋์ง ๋ณด์๋ฉด ๋ฉ๋๋ค.",
g1_h:"๋ฌด์์ ๋ง๋ค์ด์ผ ํ๋",
g1_lead:"๋ง๋ผ๋ฆฌ์ ์์ถฉ์ ์ด์๋จ๊ธฐ ์ํด <b>PfDHODH</b>๋ผ๋ ํจ์์ ์์กดํฉ๋๋ค. ์ด ํจ์๋ฅผ ๋ง์ผ๋ฉด ์์ถฉ์ด ์ฃฝ์ต๋๋ค. ๋ฌธ์ ๋ ์ฌ๋์๊ฒ๋ ๊ฐ์ ๊ณ์ด์ ํจ์๊ฐ ์๋ค๋ ๊ฒ์
๋๋ค.",
g1_a_t:"๋ง์์ผ ํ ๊ฒ", g1_a:"PfDHODH โ ๋ง๋ผ๋ฆฌ์ ์์ถฉ์ ํจ์. ์์ถฉ์ด ์์กด์ ์์กดํฉ๋๋ค.",
g1_b_t:"๊ฑด๋๋ฆฌ๋ฉด ์ ๋๋ ๊ฒ", g1_b:"์ฌ๋ DHODH โ ๊ฐ์ ๊ณ์ด. ๋ง์ผ๋ฉด ์น๋ฃ๊ฐ ์๋๋ผ ๋ฉด์ญ์ต์ ๋ถ์์ฉ์ด ๋ฉ๋๋ค.",
g1_c_t:"๋์ด์ผ ํ ๊ด๋ฌธ", g1_c:"์์ถฉ์ ์ ํ๊ตฌ ์์ ์ฝ๋๋ค. ์ ํ๊ตฌ๋ง๊ณผ ์์ถฉ๋ง, ๋ ๊ฒน์ ํต๊ณผํด์ผ ํ์ ์ ๋ฟ์ต๋๋ค.",
g2_h:"AI์๊ฒ ๊ทธ๋๋ก ๋ถ์ฌ ๋ฃ์ ํ๋กฌํํธ",
g2_lead:"์ ๋ต์ด ๋ค๋ฅธ ๋ค์ฏ ๊ฐ์ง์
๋๋ค. <b>์ด๋ค ๋ชจ๋ธ์ด๋ ์๊ด์์ต๋๋ค</b> โ OpenAI, Claude, Gemini, Qwen, KIMI, DeepSeek, ์คํ์์ค ๋ฌด์์ด๋ . ๋ณต์ฌ ๋ฒํผ์ ๋๋ฅด๊ณ ์ฐ์๋ฉด ๋ฉ๋๋ค.<br><b>๋
ธ๋ ๊ธ์จ ๋ถ๋ถ์ ๋ฐ๋์ ์๊ธฐ ๊ฒ์ผ๋ก ๋ฐ๊พธ์ญ์์ค.</b> ๊ทธ๋๋ก ์ฐ๋ฉด ๋ค๋ฅธ ์ฐธ๊ฐ์์ ๊ฐ์ ๋ถ์๊ฐ ๋์ค๊ณ , ๋จผ์ ๋ธ ์ชฝ๋ง ๋ฑ๋ก๋๋ฉฐ ๋๋จธ์ง๋ ์ค๋ณต์ผ๋ก ๋ฐ๋ ค๋ฉ๋๋ค.",
g3_h:"์์ฃผ ๊ฒช๋ ๋ฐ๋ ค ์ฌ์ ",
g3_lead:"์ ์ถ ์ฆ์ ๊ตฌ์กฐ ๊ฒ์ฌ๋ฅผ ํ๋ฏ๋ก, ์๋์ ๊ฑธ๋ฆฌ๋ฉด ์์ํ์ ์ค๋ฅด์ง ๋ชปํ๊ณ ๋ฐ๋ก ๋๋์์ต๋๋ค.",
fails:[
["๊ธฐ์ง ๋ฌผ์ง์ ์ ์ฌ์ฒด","์ ๊ท์ฑ ์ ์๊ฐ 0์ ๊ฐ๊น์ต๋๋ค. ๊ธฐ์ค๋ฌผ์ง ์์ฒด๊ฐ ์ ๊ท์ฑ 0์ ์ด๋ผ, ๊ทธ ์ ์ฌ์ฒด๋ ๊ฐ์ 0์ ๋ฌผ๋ ค๋ฐ์ต๋๋ค. ์ค์ธก์ผ๋ก ์ ์ฌ์ฒด ํ๋๊ฐ 10์ ๋ง์ ์ 0.96์ ๋ฐ์์ต๋๋ค."],
["PAINS ๊ตฌ์กฐ","์ฌ๋ฌ ํ์ ์ ๋ฌด์ฐจ๋ณ๋ก ๊ฑธ๋ฆฌ๋ ๊ตฌ์กฐ์
๋๋ค. ์๋ ๋ฐ๋ ค๋ฉ๋๋ค."],
["๋ถ์๋ {MW} ์ด๊ณผ","์๋ ๋ฐ๋ ค๋ฉ๋๋ค. ๋ฌด๊ฑฐ์ด ๋ถ์๋ก ๊ฒฐํฉ ์ ์๋ฅผ ์ฌ๋ฆฌ๋ ๊ฒ์ ๋ง๊ธฐ ์ํ ์ํ์
๋๋ค."],
["๋ถ์์ ์ ์ถ","C20H25N3O4 ๊ฐ์ ๋ถ์์์ ์ด์ฑ์ง์ฒด๊ฐ ๋๋ฌด ๋ง์ ํ๊ฐ๊ฐ ๋ถ๊ฐ๋ฅํฉ๋๋ค. SMILES ๋๋ InChI๋ก ๋ด์ญ์์ค."],
["๊ฐ์ ๊ตฌ์กฐ ์ฌ์ ์ถ","์ด๋ฏธ ๋ฑ๋ก๋ ๊ตฌ์กฐ์ ๊ฐ์ผ๋ฉด ๋ฐ๋ ค๋ฉ๋๋ค. ๋จผ์ ๋ธ ๋ถ์๊ฒ ๊ท์๋ฉ๋๋ค."],
],
g4_h:"์ ์๋ ์ด๋ป๊ฒ ๋๋๋",
g4_lead:"{WEIGHTS}<br><br><b>๊ธฐ์ค์ ๊ฐ์ถ์ง ์๋ ์ด์ ๊ฐ ์์ต๋๋ค.</b> ๋ฌด์์ด ์ ์๋ฅผ ๋ฐ๋์ง ์๋ฉด ์ฐธ๊ฐ์๊ฐ ์ค์ ๋ก ๋ ๋์ ๋ถ์๋ฅผ ๋ง๋ญ๋๋ค. ์ฐ๋ฆฌ๊ฐ ์ํ๋ ๊ฑด ๊ทธ๊ฒ์
๋๋ค.<br><br>๋ช ๊ฐ์ง ์ ์ฑ
๋ง ๋ฏธ๋ฆฌ ์๋ ค๋๋ฆฝ๋๋ค. <b>์ ๊ท์ฑ์ ํจ๋ ฅ์ ๊ณฑํด์ง๋๋ค</b> โ ์๋กญ๊ธฐ๋ง ํ๊ณ ๋ฃ์ง ์์ผ๋ฉด 0์ ์
๋๋ค. <b>ADMETยท์ ๊ท์ฑยทํฉ์ฑ์ ํ๋ณด์ฑ์ ๋น๋กํฉ๋๋ค</b> โ ์๋ฌด ํจ๊ณผ ์๋ ์์ ํ ๋ถ์๋ ์ฑ์ทจ๊ฐ ์๋๋๋ค. <b>๋ถํ์คํ ์์ธก์ ๋ฎ๊ฒ ์ฑ์ ๋ฉ๋๋ค</b> โ ์ฐ๋ฆฌ ๋๊ตฌ๊ฐ ํ์ ํ์ง ๋ชปํ๋ ํ๋ณด๋ ๊ทธ๋งํผ ๊น์
๋๋ค.<br><br>์์ํ์์ ๊ฐ ํ์ ๋ง์ฐ์ค๋ฅผ ์ฌ๋ฆฌ๋ฉด <b>์ถ๋ณ ์ ์์ ๊ทธ ๊ทผ๊ฑฐ ์์น</b>๊ฐ ๋์ต๋๋ค. ๊ทธ๋๋ก ๋ณต์ฌํด ํ๋กฌํํธ E์ ๋ฃ์ผ์๋ฉด ๋ฉ๋๋ค.",
prize_h:"์๊ธ", prize_unit:"USD",
prize_total_label:(amt,n)=>`์์ฆ ${n}๊ฐ ๋์ ์ด ์๊ธ $${amt}`,
prize_body:"๊ฐ ์์ฆ์ด ๋๋ ๋ <b>์์ํ 1์์๊ฒ ์๊ธ์ ๋๋ฆฝ๋๋ค.</b> ์ฒซ ์์ฆ(#1 ๋ง๋ผ๋ฆฌ์)์ <b>2026๋
9์ 30์ผ</b> ๋ง๊ฐ์ด๋ฉฐ ์๊ธ์ ๋ฏธํ 1,000๋ฌ๋ฌ์
๋๋ค.<br><br>์ด ๋์ ์ฌ๋ฌ๋ถ์ด ์ด ์๊ฐ๊ณผ ํ ํฐ์ ๋ํ ๋๊ฐ๊ฐ ๋๊ธฐ์๋ ํฑ์์ด ๋ถ์กฑํฉ๋๋ค. ๊ทธ๋ ๊ฒ ๊ณ์ฐํ ์๊ฐ๋ ์์ต๋๋ค. <b>์ด๊ฒ์ โ๋น์ ์ด ํ ์ผ์ ๊ฐ์ด ์์๋คโ๊ณ ๋งํ๋ ๋ฐฉ์์
๋๋ค.</b><br><br>์์ธ์งํ ์ฐ๊ตฌ๊ฐ ํ๋ ์ด์ ๋ ์๋ฌด๋ ๊ณ ๋ง๋ค๊ณ ํ์ง ์๊ธฐ ๋๋ฌธ์
๋๋ค. ๋
ผ๋ฌธ๋ ์ ์ ์ค๋ฆฌ๊ณ , ํฌ์๋ ์ ๋ถ๊ณ , ์๋ฌด๋ ๋ณด์ง ์์ต๋๋ค. ์ด ๋ํ๋ ์ต์ํ ๋๊ฐ ๋ฌด์์ ๊ธฐ์ฌํ๋์ง ๊ธฐ๋ก์ผ๋ก ๋จ๊ธฐ๊ณ , ์์ฆ๋ง๋ค ํ ๋ฒ ๊ฐ์ฌ๋ฅผ ํํฉ๋๋ค.",
prize_fine:"์์ฆ๋ง๋ค ๋์ ์ง๋ณ์ด ๋ฐ๋๋๋ค. ยท ์๊ธ์ ๋ฏธํ(USD) ๊ธฐ์ค์ด๋ฉฐ ์ง๊ธ ๋ฐฉ๋ฒ์ ์์์์ ํ์ํ์ฌ ์ ํฉ๋๋ค. ยท <b>ํ์์ฌ๊ฐ ํ๋ณด๋๋ฉด ์๊ธ ๊ท๋ชจ๋ ์ํฅ๋ ์ ์์ต๋๋ค.</b> ยท ์์์๋ Space ์ปค๋ฎค๋ํฐ ํญ์ ๊ณต์งํฉ๋๋ค. ยท ๋์ ์ ๋จผ์ ์ ์ถํ ๋ถ์ด ์ฐ์ ํฉ๋๋ค. ยท ๋ฒ๋ น์ ์ง๊ธ์ด ๋ถ๊ฐ๋ฅํ ๊ฒฝ์ฐ๋ ์ ์ธ๋ ์ ์์ต๋๋ค.",
own_h:"์ ์ถํ ๋ถ์๋ ์ฌ๋ฌ๋ถ์ ๊ฒ์
๋๋ค",
own_keep:"<b>์์ ๊ถ์ ์ ์ ์ผ๋ก ์ ์ถ์์๊ฒ ์์ต๋๋ค.</b> VIDRAFT๋ ์ฑ์ ๊ณผ ์์ํ ํ์์ ํ์ํ ๋ฒ์์์๋ง ์ฌ์ฉํ๋ฉฐ, ํนํยท์์ ๊ถ์ ๊ฐ์ ธ๊ฐ์ง ์๊ณ ์ 3์์๊ฒ ์ ๊ณตํ์ง ์์ผ๋ฉฐ ์์ฌ ํ์ดํ๋ผ์ธ์ ํฌ์
ํ์ง ์์ต๋๋ค.",
own_body:"๊ณต๊ฐ ์ฌ๋ถ๋ ์ ์ถ์๊ฐ ์ ํฉ๋๋ค. <b>๋น๊ณต๊ฐ</b>๋ฅผ ์ ํํ๋ฉด ์์ํ์๋ ํ๋ณด IDยท๊ณจ๊ฒฉ ํด์ยท๋ถ์๋ ๊ตฌ๊ฐยท์ ์๋ง ํ์๋๊ณ ๊ตฌ์กฐ๋ ๋์ค์ง ์์ต๋๋ค. <b>๊ณต๊ฐ</b>๋ฅผ ์ ํํ๋ฉด ์ ์ฒด ๊ตฌ์กฐ๊ฐ ํ์๋์ด ๋ค๋ฅธ ์ฐธ๊ฐ์๊ฐ ๋ณด๊ณ ๋ฐฐ์ธ ์ ์์ต๋๋ค.",
own_warn:"โ ๏ธ <b>๋ ๊ฐ์ง๋ฅผ ๋ถ๋ช
ํ ๋ง์๋๋ฆฝ๋๋ค.</b><br>โ ๋น๊ณต๊ฐ๋ <b>๋ค๋ฅธ ์ฐธ๊ฐ์์ ๋์ค์๊ฒ</b> ๊ณต๊ฐํ์ง ์๋๋ค๋ ๋ป์
๋๋ค. ์ฑ์ ํ๋ ค๋ฉด ๊ตฌ์กฐ๊ฐ ํ์ํ๋ฏ๋ก VIDRAFT ์์คํ
์๋ ์ ์ฅ๋๋ฉฐ, ์ฑ์ ์ธ ๋ชฉ์ ์ผ๋ก ์ฐ์ง ์์ต๋๋ค.<br>โก <b>๊ณต๊ฐ๋ฅผ ์ ํํ๋ฉด ํนํ ์ ๊ท์ฑ์ ์์ ์ ์์ต๋๋ค.</b> ๊ตฌ์กฐ๋ฅผ ๊ณต๊ฐํ๋ ์๊ฐ ๊ณต์ง(disclosure)๊ฐ ๋์ด ์ดํ ๊ทธ ๋ฌผ์ง๋ก ํนํ๋ฅผ ๋ฐ๊ธฐ ์ด๋ ค์์ง ์ ์์ต๋๋ค. ์์
์ ํ์ฉ์ ์ผ๋์ ๋์
จ๋ค๋ฉด <b>๋น๊ณต๊ฐ๋ฅผ ์ ํํ๊ณ ์ถ์์ ๋จผ์ ํ์๊ธฐ ๋ฐ๋๋๋ค.</b>",
l_vis:"๊ณต๊ฐ ์ฌ๋ถ", vis_priv:"๐ ๋น๊ณต๊ฐ (๊ธฐ๋ณธ)", vis_pub:"๐ ์ ์ฒด ๊ตฌ์กฐ ๊ณต๊ฐ",
chart_h:"AI ๋ชจ๋ธ๋ณ ์ฑ๊ณผ",
chart_sub:"์ด๋ ๋ชจ๋ธ์ด <b>๊ฐ์ฅ ์ข์ ํ๋ณด</b>๋ฅผ ๋๋์ง(๋ง๋)์ <b>์ผ๋ง๋ ์ฐ์ด๋์ง</b>(์ค๋ฅธ์ชฝ)๋ฅผ ํจ๊ป ๋ด
๋๋ค. ๋ง์ด ์ฐ์ธ๋ค๊ณ ์ํ๋ ๊ฒ์ ์๋๋ฏ๋ก ๋ฐ๋ก ํ์ํฉ๋๋ค.",
chart_empty:"์ฑ์ ๋ ์ ์ถ์ด ์์ด๋ฉด ๋ชจ๋ธ๋ณ ์ฑ๊ณผ๊ฐ ์ฌ๊ธฐ์ ํ์๋ฉ๋๋ค.",
lg_best:"์ต๊ณ ์ ์", lg_mean:"ํ๊ท ", lg_use:"์ ์ถ ์",
mcounts:(m,n)=>"๋ชจ๋ธ "+m+" ยท ์ ์ถ "+n,
signin:"Hugging Face๋ก ๋ก๊ทธ์ธ", signout:"๋ก๊ทธ์์",
gate:"์ ์ถํ๋ ค๋ฉด <b>Hugging Face ๋ก๊ทธ์ธ</b>์ด ํ์ํฉ๋๋ค. ์ ์ถ์ ๊ณ์ ์ด ์์ํ์ ํจ๊ป ํ์๋๋ฉฐ, ์ด๋ ๋ค๋ฅธ ์ฌ๋ ์ด๋ฆ์ผ๋ก ์ฌ๋ฆฌ๋ ๊ฒ์ ๋ง๊ณ ๋ชจ๋ธ๋ณ ์ง๊ณ๋ฅผ ์ ๋ขฐํ ์ ์๊ฒ ํฉ๋๋ค.",
entrants:"๋ช
์ฐธ๊ฐ",
l_struct:"๋ถ์ ๊ตฌ์กฐ์ (SMILES ๋๋ InChI)", l_name:"ํ์ ID (์ด๋ฆยท์์ยท๋๋ค์)",
l_model:"์ฌ์ฉ ๋ชจ๋ธ๋ช
(์ ํ)", l_why:"์ค๊ณ ๊ทผ๊ฑฐ (์ ํ)",
cols:{rank:"#",cand:"ํ๋ณด",user:"์ ์ถ์",who:"๋ชจ๋ธ",date:"์ ์ถ์ผ",activity:"์ฝํจ",binding:"๊ฒฐํฉ",
selectivity:"์ ํ์ฑ",admet:"ADMET",novelty:"์ ๊ท",synthesis:"ํฉ์ฑ",total:"์ด์ "},
counts:(a,b)=>`์ ์ถ ${a} ยท ๊ธฐ์ค๋ฌผ์ง ${b}`,
prange:(a,b,n)=>`${a.toLocaleString()}โ${b.toLocaleString()} / ์ ์ฒด ${n.toLocaleString()}`,
empty:"์์ง ์ฑ์ ๋ ์ ์ถ์ด ์์ต๋๋ค.", loading:"๋ถ๋ฌ์ค๋ ์คโฆ",
anchor:"๊ธฐ์ค", relegated:"๊ฐ๋ฑ", ref:"๊ธฐ์ค๋ฌผ์ง", reactive:"๋ฐ์์ฑ",
boardnote:"<b>๊ธฐ์ค๋ฌผ์ง(๋
ธ๋ ํ)์ ์ ์๋ฅผ ๋ฐ๋ ๋ฑ์๋ฅผ ๊ฐ์ง ์์ต๋๋ค.</b> ์ฒ๋๋ฅผ ๋์ผ๋ก ํ์ธํ์๋ผ๊ณ ๋ฃ์์ต๋๋ค.<br>๊ตฌ์กฐ๋ ์ ์ฒด ๊ณต๊ฐํ์ง ์์ต๋๋ค โ ๊ณจ๊ฒฉ ํด์์ ๋ถ์๋ ๊ตฌ๊ฐ๋ง ํ์๋๋ฉฐ ์๋ณธ์ ๋น๊ณต๊ฐ๋ก ๋ณด๊ด๋ฉ๋๋ค.<br>์ ์๋ <b>๊ณ์ฐ ๊ธฐ๋ฐ ํ๋ณด ํ๊ฐ</b>์ด๋ฉฐ ์ค์ ํจ๋ฅยท์์ ์ฑ์ด๋ ์น์ธ์ฝ๊ณผ์ ์ฐ์ด์ ๋ปํ์ง ์์ต๋๋ค.<br>์ด ์ ๋ชฉ์ ๋๋ฌ ์ ๋ ฌํ ์ ์์ต๋๋ค.",
formnote:"๋ถ์์(C20H25N3O4 ๋ฑ)์ ๋ฐ์ง ์์ต๋๋ค โ ์ด์ฑ์ง์ฒด๊ฐ ๋๋ฌด ๋ง์ ํ๊ฐ๊ฐ ๋ถ๊ฐ๋ฅํฉ๋๋ค.<br>์ ์ถ ์ฆ์ ๊ตฌ์กฐ ๊ฒ์ฌ๋ฅผ ๊ฑฐ์น๊ณ , ์ฑ์ ์ GPU ์์
๋๊ธฐ์ด์์ ์ฒ๋ฆฌ๋ฉ๋๋ค(์ ๋ถ ์์).",
need:"๊ตฌ์กฐ์ ํ์ ID๋ ํ์์
๋๋ค.", fail:"์์ฒญ ์คํจ: ", rejected:"์ ์ถ์ด ๊ฑฐ๋ถ๋์์ต๋๋ค",
busy:"์ ์ฅ์๊ฐ ํผ์กํด ์ ์๋ฅผ ํ์ ํ์ง ๋ชปํ์ต๋๋ค. ์ ์ ๋ค ๊ทธ๋๋ก ๋ค์ ์ ์ถํ์ธ์ - ํน์ ๋จผ์ ๊ธฐ๋ก๋๋ค๋ฉด ์ค๋ณต์ผ๋ก ์๋ด๋ฉ๋๋ค.",
queued:(id,n,note)=>`์ ์๋์์ต๋๋ค ยท ${id} ยท ๋๊ธฐ ${n}๊ฑด. ${note}`,
auto:"๋ธ๋ผ์ฐ์ ์ค์ ์์ ์๋ ์ ํ", manual:"์ง์ ์ ํํจ",
},
en:{
xlink:`๐ <b>Open Materials Challenge</b> <em>โ the sister challenge, for battery materials</em> โ`,
xlink2:`๐ฏ <b>LEADBOARD</b> <em>โ the benchmark for drug prediction tools</em> โ`,
topic:"Malaria", board:"Leaderboard", submit:"Submit", btn:"Submit entry",
concept:"Verifying and evaluating <b>AI-discovered malaria drug candidates</b>",
tagline:"However you found the candidate, it is checked computationally against the same rubric and scored. The target is PfDHODH, an enzyme the malaria parasite depends on; the human counterpart must be left alone.",
how_h:"How to take part",
why:"<b>Malaria kills about 597,000 people a year, and roughly three quarters of them are children who never reach five</b> (WHO World Malaria Report 2024, 2023 estimates). Not for want of chemistry - for want of a market, because the patients are poor. Which is exactly where people working from conviction rather than return can still change the outcome.<br><br>AI already produces drug candidates in volume. The bottleneck is no longer discovery but <b>the means to check whether a candidate is any good</b>. A model will draw plausible molecules all day; it cannot tell you whether they kill the parasite, harm the patient, or can be made at all. This challenge publishes that check โ <b>bring what your AI found, and it is verified computationally and ranked on the same scale as everyone else's.</b>",
s1_h:"1. Design a candidate with any AI",
s1_p:"OpenAI, Claude, Gemini, Qwen, KIMI, DeepSeek โ any model, any harness, or by hand. The goal is a small molecule that blocks PfDHODH, an enzyme the malaria parasite depends on.",
s2_h:"2. Submit the structure",
s2_p:"Enter it as SMILES or InChI. Every entry is structure-checked on arrival for reactivity, PAINS and duplicates. Molecular formulas are not accepted โ too many isomers.",
s3_h:"3. It is scored and ranked automatically",
s3_p:"VIDRAFT's PharmaOS and CellOS compute activity, target binding, selectivity, toxicity, novelty and synthetic accessibility out of 100, and the table orders entries by score. Reference compounds sit in the same table so you can read what your number means.",
ov_axes:{activity:"Activity",binding:"Binding",selectivity:"Selectivity",admet:"ADMET",novelty:"Novelty",synthesis:"Synthesis"},
ov_why:{
activity:d=>`whole-cell pAct, lower bound ${d.pAct_q10 ?? "โ"}`,
binding:d=>`pIC50 ${d.pIC50 ?? "โ"} ยท ligand efficiency ${d.LE ?? "โ"}`,
selectivity:d=>`${d.fold ?? "โ"}x over human ยท engagement ${d.target_engagement ?? "โ"}`,
admet:d=>`desirability, geometric mean ${d.geometric_mean ?? "โ"}`,
novelty:d=>`nearest known compound ${d.max_tanimoto ?? "โ"}`,
synthesis:d=>`SA score ${d.sa_score ?? "โ"} (1 easy - 10 hard)`,
},
ov_pred:"Predicted", ov_pf:"parasite enzyme", ov_hs:"human enzyme", ov_sel:"selectivity",
private_note:"structure withheld by the entrant", copy_smiles:"Copy SMILES",
tally_label:"entries", daily_cap:"Up to 30 entries per account per day, resetting at midnight KST.",
season_soon:"soon", season_notopen:"This season is not taking entries yet. It opens once the scorer has been checked, and we will say so.",
cd_label:"Season #1 closes in", cd_day:"Day", cd_over_label:"Season #1 closed",
cd_over:"closed", view_3d:"View in 3D",
v3_loading:"building conformer\u2026", v3_atoms:"atoms",
v3_failed:"could not build a 3D conformer",
private_full:"The entrant chose to keep this structure private. It is identified only by its candidate ID and skeleton hash.",
reasons:{
parse: r=>"Structure could not be parsed (submit SMILES or InChI)",
covalent: r=>`Covalent warhead detected (${r.arg}) โ Season 1 is a non-covalent track`,
mw: r=>`Molecular weight ${r.arg} > ${r.limit}`,
heavy: r=>`Heavy atoms ${r.arg} > ${r.limit}`,
pains: r=>`PAINS motif (${r.arg})`,
duplicate: r=>"This structure has already been entered",
ames: r=>`Predicted mutagenicity (Ames) ${r.arg} > ${r.limit}`,
solubility: r=>`Extreme insolubility (logS ${r.arg} < ${r.limit})`,
},
ov_none:"No scoring detail was recorded for this entry.",
ov_foot:"All values are computed predictions, not measurements, and are not claims about real efficacy or safety.",
tab_board:"Leaderboard",tab_models:"Model standings", tab_guide:"Entrant guide",
ge_h:"What does the scoring",
ge_lead:"Every entry is assessed by two VIDRAFT systems working together. One asks how the molecule behaves against the target; the other asks what that means in a living cell and a whole body.",
ge_p_role:"molecule ยท target", ge_c_role:"cell ยท organism",
ge_p_body:"Whether the molecule actually binds the target protein, how tightly, and whether that affinity was designed or simply bought with bulk.",
ge_p_list:["Docking against the parasite enzyme and the human one","Binding efficiency relative to size โ so mass cannot buy points","Structural distance from known antimalarial chemical space","Synthetic accessibility"],
ge_c_body:"Binding is not a drug. Whether the parasite dies, whether the patient is harmed, and whether the compound survives a body at all.",
ge_c_list:["Whole-cell antimalarial activity โ does the parasite die","Absorption, distribution, metabolism, excretion and toxicity","Avoiding the human enzyme โ no immunosuppression","Uncertain predictions score lower โ confidence is rewarded"],
ge_proof:"<b>Why trust the scoring.</b> Our predictive models hold <b>first place across 16 tracks of the public benchmark Polaris Hub</b>, spanning absorption, distribution, metabolism, toxicity, potency and kinase selectivity. The most recent is <b>MDR1-MDCK efflux ratio</b> (11 Aug 2026, correlation 0.802 against 0.725 for second). All sixteen are named below under the slugs Polaris uses, so you can look each one up.",
ge_caveat:"โ ๏ธ All sixteen were checked to exist as Polaris benchmarks. Polaris does not expose placements through a public API, so the rankings themselves cannot be verified automatically from outside.<br>Whether <em>this</em> contest scores honestly is easier to check โ <b>approved drugs and inert compounds sit in the same table as the entries.</b> See whether the clinical candidate lands at the top and caffeine and ibuprofen land at the bottom.",
g1_h:"What you are designing",
g1_lead:"The malaria parasite depends on an enzyme called <b>PfDHODH</b> to survive. Block it and the parasite dies. The complication is that we have a close relative of that enzyme ourselves.",
g1_a_t:"Block this", g1_a:"PfDHODH โ the parasite's enzyme. It cannot survive without it.",
g1_b_t:"Leave this alone", g1_b:"Human DHODH โ the homologue. Inhibiting it gives immunosuppression, not a cure.",
g1_c_t:"Get past this", g1_c:"The parasite lives inside a red blood cell. Two membranes stand between your compound and the target.",
g2_h:"Prompts to paste into your model",
g2_lead:"Five, each with a different strategy. <b>Any model works</b> โ OpenAI, Claude, Gemini, Qwen, KIMI, DeepSeek, open weights, whatever you use. Copy and go.<br><b>Change the highlighted part.</b> Used verbatim, these produce the same molecules for everyone; the first submission is registered and the rest come back as duplicates.",
g3_h:"Why entries get rejected",
g3_lead:"Structures are checked on arrival, so anything below comes straight back rather than reaching the table.",
fails:[
["Analogue of a known drug","Novelty lands near zero. The reference compound scores zero there itself, and an analogue inherits it โ one tested analogue scored 0.96 out of 10."],
["PAINS motif","Structures that hit many targets indiscriminately. Rejected automatically."],
["Molecular weight over {MW}","Rejected. The cap stops binding scores being bought with sheer mass."],
["A molecular formula","C20H25N3O4 and the like have too many isomers to evaluate. Submit SMILES or InChI."],
["A structure already entered","Duplicates are rejected and credited to whoever submitted first."],
],
g4_h:"How the points divide",
g4_lead:"{WEIGHTS}<br><br><b>The rubric is published on purpose.</b> An entrant who knows what earns points produces better molecules than one who is guessing, and better molecules are the entire objective.<br><br>A few policies worth knowing up front. <b>Novelty is multiplied by potency</b> โ new and inert is worth nothing. <b>ADMET, novelty and synthesis scale with how much of a candidate the molecule is</b> โ a perfectly safe compound that does nothing has achieved nothing. <b>Uncertain predictions score lower</b> โ where our tools are unsure, you are marked down accordingly.<br><br>Hover any row on the leaderboard to see <b>every axis and the numbers behind it</b>. Copy that into prompt E.",
prize_h:"Prize", prize_unit:"USD",
prize_total_label:(amt,n)=>`$${amt} in total across ${n} seasons`,
prize_body:"When a season closes, <b>the entry at the top of the table receives a prize.</b> Season #1 (Malaria) closes on <b>30 September 2026</b> and carries USD 1,000.<br><br>This does not come close to paying for the time and tokens you spent, and it is not meant to. <b>It is a way of saying that what you did had worth.</b><br><br>Neglected-disease work is thankless by construction: the papers are hard to place, the funding is not there, and mostly nobody looks. This challenge at least records who contributed what, and says thank you once a season.",
prize_fine:"Each season targets a different disease. ยท The prize is denominated in USD; the method of payment is agreed with the recipient. ยท <b>Should sponsors come on board, the amount may increase.</b> ยท Winners are announced in the Space community tab. ยท Ties go to whoever submitted first. ยท Payment may be withheld where law forbids it.",
own_h:"Your molecule stays yours",
own_keep:"<b>Ownership remains entirely with the entrant.</b> VIDRAFT uses a submission only to score it and to display it on the table. We take no patent or ownership interest, pass nothing to third parties, and put nothing into our own pipeline.",
own_body:"You also decide who sees it. Choose <b>private</b> and the table shows only a candidate ID, a skeleton hash, a molecular-weight band and the scores. Choose <b>public</b> and the full structure is shown, so other entrants can learn from it.",
own_warn:"โ ๏ธ <b>Two things stated plainly.</b><br>1. Private means hidden from other entrants and the public. Scoring needs the structure, so it is stored on VIDRAFT systems and used for nothing else.<br>2. <b>Making a structure public can cost you patentability.</b> Publication is disclosure, and disclosure can bar a later patent on that compound. If you have any commercial intent, <b>keep it private and file first.</b>",
l_vis:"Visibility", vis_priv:"๐ Private (default)", vis_pub:"๐ Publish full structure",
chart_h:"Model standings",
chart_sub:"Which model produced the <b>best candidate</b> (bar) alongside <b>how much it gets used</b> (right). Popularity is not quality, so the two are shown separately.",
chart_empty:"Model standings appear here once scored entries accumulate.",
lg_best:"best score", lg_mean:"mean", lg_use:"entries",
mcounts:(m,n)=>m+" models ยท "+n+" entries",
signin:"Sign in with Hugging Face", signout:"Sign out",
gate:"Submitting requires a <b>Hugging Face sign-in</b>. Your account is shown next to your entry, which stops anyone posting under someone else's name and keeps the per-model chart trustworthy.",
entrants:"entrants",
l_struct:"Structure (SMILES or InChI)", l_name:"Display ID (name, affiliation or handle)",
l_model:"Model used (optional)", l_why:"Design rationale (optional)",
cols:{rank:"#",cand:"Candidate",user:"Entrant",who:"Model",date:"Submitted",activity:"Activity",binding:"Binding",
selectivity:"Select.",admet:"ADMET",novelty:"Novelty",synthesis:"Synth.",total:"Total"},
counts:(a,b)=>`${a} entries ยท ${b} references`,
prange:(a,b,n)=>`${a.toLocaleString()}โ${b.toLocaleString()} of ${n.toLocaleString()}`,
empty:"No scored entries yet.", loading:"Loadingโฆ",
anchor:"REF", relegated:"RELEG.", ref:"reference", reactive:"reactive",
boardnote:"<b>Reference compounds (amber rows) are scored but never ranked.</b> They are there so you can see the scale.<br>Structures are not published in full โ only a skeleton hash and a molecular-weight band; the original is held privately.<br>Scores are a <b>computational assessment of candidates</b>. They are not a claim about real efficacy or safety, nor a comparison against approved drugs.<br>Click a column header to sort.",
formnote:"Molecular formulas (C20H25N3O4 and the like) are not accepted โ too many isomers to evaluate.<br>Entries are structure-checked on submission; scoring runs on a GPU queue and takes a few minutes.",
need:"Structure and display ID are required.", fail:"Request failed: ", rejected:"Entry rejected",
busy:"The ledger was too busy to confirm this entry. Resubmit the same candidate in a moment - if it did land, you will be told it is a duplicate.",
queued:(id,n,note)=>`Accepted ยท ${id} ยท ${n} in queue. ${note}`,
auto:"detected from your browser", manual:"chosen by you",
}
};
// The visitor's own setting decides; the toggle can still override it.
let LANG = (function(){
const n = (navigator.languages && navigator.languages[0]) || navigator.language || "en";
return String(n).toLowerCase().startsWith("ko") ? "ko" : "en";
})();
let LANG_AUTO = true;
const COLS = ["rank","cand","user","who","date","activity","binding","selectivity","admet","novelty","synthesis","total"];
const AX = ["activity","binding","selectivity","admet","novelty","synthesis"];
let DATA = null, sortKey = "total", sortDir = -1;
// Large seasons are drawn one page at a time rather than all at once.
const PAGE_SIZE = 500;
let page = 0;
const $ = s => document.querySelector(s);
// Which season the whole page is showing. Kept in the URL so a link to a season is a
// link to that season, and remembered so a return visit lands where the reader left off.
let SEASON = (function(){
const u = new URLSearchParams(location.search).get("season");
const v = u || localStorage.getItem("odc_season") || "1";
return parseInt(v, 10) || 1;
})();
let SEASONS = null;
function seasonInfo(){
return (SEASONS || []).find(s => s.number === SEASON) || null;
}
function qs(){ return "?season=" + SEASON; }
const f1 = v => (v==null||v==="") ? "โ" : (+v).toFixed(1);
// totals carry three decimals; the per-axis columns stay at one, where the extra digits
// would be width without information
const f3 = v => (v==null||v==="") ? "โ" : (+v).toFixed(3);
// ---------------------------------------------------------------- season copy
// Only what actually differs between seasons. Everything else lives in T and is shared,
// so a new season is a block of writing rather than an edit to the page.
const ST = {
ko: {
1: {
topic:"๋ง๋ผ๋ฆฌ์",
concept:"<b>AI๊ฐ ๋ฐ๊ฒฌํ ๋ง๋ผ๋ฆฌ์ ์ ์ฝ ํ๋ณด ๋ฌผ์ง</b>์ ๊ฒ์ฆ ๋ฐ ํ๊ฐ",
tagline:"์ด๋ค AI๋ก ์ฐพ์๋ธ ํ๋ณด๋ , ๊ฐ์ ๊ธฐ์ค์ผ๋ก ๊ณ์ฐ ๊ฒ์ฆํ๊ณ ์ ์๋ฅผ ๋งค๊น๋๋ค. ํ์ ์ ๋ง๋ผ๋ฆฌ์ ์์ถฉ์ด ์์กดํ๋ ํจ์ PfDHODH์ด๋ฉฐ, ์ฌ๋์ ๊ฐ์ ํจ์(DHODH)๋ ๊ฑด๋๋ฆฌ์ง ์์์ผ ํฉ๋๋ค.",
s1_p:"OpenAI ยท Claude ยท Gemini ยท Qwen ยท KIMI ยท DeepSeek ๋ฑ ์ด๋ค ๋ชจ๋ธ์ด๋ , ์ด๋ค ํ๋ค์ค๋ ์์ ์
๋๋ค. ์ง์ ์ค๊ณํด๋ ๋ฉ๋๋ค. ๋ง๋ผ๋ฆฌ์ ์์ถฉ ํจ์ PfDHODH๋ฅผ ๋ง์ ์ ๋ถ์๋ฅผ ์ฐพ์ผ์ธ์.",
ov_pf:"๋ง๋ผ๋ฆฌ์ ํจ์", ov_hs:"์ฌ๋ ํจ์",
g1_lead:"๋ง๋ผ๋ฆฌ์ ์์ถฉ์ ์ด์๋จ๊ธฐ ์ํด <b>PfDHODH</b>๋ผ๋ ํจ์์ ์์กดํฉ๋๋ค. ์ด ํจ์๋ฅผ ๋ง์ผ๋ฉด ์์ถฉ์ด ์ฃฝ์ต๋๋ค. ๋ฌธ์ ๋ ์ฌ๋์๊ฒ๋ ๊ฐ์ ๊ณ์ด์ ํจ์๊ฐ ์๋ค๋ ๊ฒ์
๋๋ค.",
g1_a:"PfDHODH โ ๋ง๋ผ๋ฆฌ์ ์์ถฉ์ ํจ์. ์์ถฉ์ด ์์กด์ ์์กดํฉ๋๋ค.",
g1_b:"์ฌ๋ DHODH โ ๊ฐ์ ๊ณ์ด. ๋ง์ผ๋ฉด ์น๋ฃ๊ฐ ์๋๋ผ ๋ฉด์ญ์ต์ ๋ถ์์ฉ์ด ๋ฉ๋๋ค.",
cd_label:"์์ฆ #1 ๋ง๊ฐ๊น์ง", cd_over_label:"์์ฆ #1 ๋ง๊ฐ",
prize_amt:"$1,000",
prize_body:"๊ฐ ์์ฆ์ด ๋๋ ๋ <b>์์ํ 1์์๊ฒ ์๊ธ์ ๋๋ฆฝ๋๋ค.</b> ์์ฆ #1(๋ง๋ผ๋ฆฌ์)์ <b>2026๋
9์ 30์ผ</b> ๋ง๊ฐ์ด๋ฉฐ ์๊ธ์ ๋ฏธํ 1,000๋ฌ๋ฌ์
๋๋ค.<br><br>์ด ๋์ ์ฌ๋ฌ๋ถ์ด ์ด ์๊ฐ๊ณผ ํ ํฐ์ ๋ํ ๋๊ฐ๊ฐ ๋๊ธฐ์๋ ํฑ์์ด ๋ถ์กฑํฉ๋๋ค. ๊ทธ๋ ๊ฒ ๊ณ์ฐํ ์๊ฐ๋ ์์ต๋๋ค. <b>์ด๊ฒ์ โ๋น์ ์ด ํ ์ผ์ ๊ฐ์ด ์์๋คโ๊ณ ๋งํ๋ ๋ฐฉ์์
๋๋ค.</b><br><br>์์ธ์งํ ์ฐ๊ตฌ๊ฐ ํ๋ ์ด์ ๋ ์๋ฌด๋ ๊ณ ๋ง๋ค๊ณ ํ์ง ์๊ธฐ ๋๋ฌธ์
๋๋ค. ๋
ผ๋ฌธ๋ ์ ์ ์ค๋ฆฌ๊ณ , ํฌ์๋ ์ ๋ถ๊ณ , ์๋ฌด๋ ๋ณด์ง ์์ต๋๋ค. ์ด ๋ํ๋ ์ต์ํ ๋๊ฐ ๋ฌด์์ ๊ธฐ์ฌํ๋์ง ๊ธฐ๋ก์ผ๋ก ๋จ๊ธฐ๊ณ , ์์ฆ๋ง๋ค ํ ๋ฒ ๊ฐ์ฌ๋ฅผ ํํฉ๋๋ค."
},
2: {
topic:"๊ฒฐํต",
concept:"<b>AI๊ฐ ๋ฐ๊ฒฌํ ๊ฒฐํต ์ ์ฝ ํ๋ณด ๋ฌผ์ง</b>์ ๊ฒ์ฆ ๋ฐ ํ๊ฐ",
tagline:"์ด๋ค AI๋ก ์ฐพ์๋ธ ํ๋ณด๋ , ๊ฐ์ ๊ธฐ์ค์ผ๋ก ๊ณ์ฐ ๊ฒ์ฆํ๊ณ ์ ์๋ฅผ ๋งค๊น๋๋ค. ํ์ ์ ๊ฒฐํต๊ท ์ด ์ธํฌ๋ฒฝ์ ๋ง๋๋ ๋ฐ ์ฐ๋ ํจ์ InhA์ด๋ฉฐ, ์ฌ๋์ ๊ฐ์ ํํ์ ๋ด๋นํ๋ ํจ์(FASN ์๋
ธ์ผํ์ํจ์ ์์ญ)๋ ๊ฑด๋๋ฆฌ์ง ์์์ผ ํฉ๋๋ค.",
why:"<b>๊ฒฐํต์ ํ ํด ์ฝ 125๋ง ๋ช
์ ๋ชฉ์จ์ ๊ฐ์ ธ๊ฐ๋๋ค. ๋จ์ผ ๊ฐ์ผ๋ณ์ผ๋ก๋ ์ธ๊ณ ์ต๋ค์
๋๋ค</b>(WHO ์ธ๊ณ ๊ฒฐํต ๋ณด๊ณ ์ 2024). ์น๋ฃ์ ๋ ์์ต๋๋ค. ๋ค๋ง <b>6๊ฐ์์ ๋งค์ผ ๋จน์ด์ผ ํ๊ณ </b>, ๊ทธ๋ง์ ๋ ๋ฃ์ง ์๋ ๋ด์ฑ๊ท ์ด ๊ณ์ ๋๊ณ ์์ต๋๋ค. ๋ค์ ๋ด์ฑ ๊ฒฐํต ํ์๋ 1๋
๋๊ฒ ์ฝ์ ๋จน๊ณ ๋ ์ ๋ฐ ๊ฐ๊น์ด ๋ซ์ง ๋ชปํฉ๋๋ค.<br><br>์ ํญ๊ฒฐํต์ ๊ฐ ๋๋ฌธ ์ด์ ๋ ๊ณผํ์ด ๋งํ์๊ฐ ์๋๋๋ค. ํ์ ๋๋ถ๋ถ์ด ๊ฐ๋ํ ๋๋ผ์ ์์ด ์์ฅ์ด ์ฑ๋ฆฝํ์ง ์๊ธฐ ๋๋ฌธ์
๋๋ค. 40๋
๋๊ฒ ์ ์ฝ์ด ํ๋๋ ๋์ค์ง ์๋ค๊ฐ 2012๋
์์ผ ๋ฒ ๋คํผ๋ฆฐ์ด ์น์ธ๋์ต๋๋ค.<br><br>์์ฆ #2๋ ๊ทธ ์๋ฆฌ๋ฅผ ๊ฒจ๋ฅํฉ๋๋ค. <b>AI๊ฐ ๊ทธ๋ ค๋ธ ํ๋ณด๋ฅผ ๋ฐ์, ๊ฐ์ ์ฃ๋๋ก ๊ณ์ฐ ๊ฒ์ฆํ๊ณ ์์๋ฅผ ๋งค๊น๋๋ค.</b>",
s1_p:"OpenAI ยท Claude ยท Gemini ยท Qwen ยท KIMI ยท DeepSeek ๋ฑ ์ด๋ค ๋ชจ๋ธ์ด๋ , ์ด๋ค ํ๋ค์ค๋ ์์ ์
๋๋ค. ์ง์ ์ค๊ณํด๋ ๋ฉ๋๋ค. ๊ฒฐํต๊ท ํจ์ InhA๋ฅผ ๋ง์ ์ ๋ถ์๋ฅผ ์ฐพ์ผ์ธ์.",
ov_pf:"๊ฒฐํต๊ท ํจ์", ov_hs:"์ฌ๋ ํจ์",
g1_lead:"๊ฒฐํต๊ท ์ ์ธํฌ๋ฒฝ์ ์ง๋ฐฉ์ฐ์ ๋ง๋ค ๋ <b>InhA</b>๋ผ๋ ํจ์๋ฅผ ์๋๋ค. ๊ฒฐํต ํ์ค ์น๋ฃ์ ์ธ ์ด์๋์์ง๋๊ฐ ์ค์ ๋ก ๋ง๋ ํจ์๊ฐ ์ด๊ฒ์
๋๋ค. ๋ฌธ์ ๋ ์ฌ๋์๊ฒ๋ ๊ฐ์ ํํ์ ํ๋ ํจ์๊ฐ ์๋ค๋ ๊ฒ์
๋๋ค.",
g1_a:"InhA โ ๊ฒฐํต๊ท ์ ์๋
ธ์ผํ์ํจ์. ์ด์๋์์ง๋ยท์ํฐ์ค๋๋ฏธ๋๊ฐ ์์ฉํ๋ ์๋ฆฌ์
๋๋ค.",
g1_b:"์ฌ๋ FASN์ ์๋
ธ์ผํ์ํจ์ ์์ญ โ ๊ฐ์ ํํ. ๋ง์ผ๋ฉด ์ง๋ฐฉ์ฐ ํฉ์ฑ์ด ํจ๊ป ๋ฉ์ถฅ๋๋ค.",
g1_c:"๊ฒฐํต๊ท ์ ๋ฐ๋ ๊ฐ์ ๋ง์ด์ฝ์ฐ ์ธํฌ๋ฒฝ์ ์ธ์ฌ ์์ต๋๋ค. ์ฌ๋งํ ์ธ๊ท ๋ณด๋ค ํจ์ฌ ๋ ํฌ๊ณผ๋๊ณ , ๋ฐฐ์ถ ํํ๋ ํ๋ฐํฉ๋๋ค.",
cd_label:"์์ฆ #2 ๋ง๊ฐ๊น์ง", cd_over_label:"์์ฆ #2 ๋ง๊ฐ",
prize_amt:"$2,000",
prize_body:"๊ฐ ์์ฆ์ด ๋๋ ๋ <b>์์ํ 1์์๊ฒ ์๊ธ์ ๋๋ฆฝ๋๋ค.</b> ์์ฆ #2(๊ฒฐํต)๋ <b>2026๋
10์ 31์ผ</b> ๋ง๊ฐ์ด๋ฉฐ ์๊ธ์ ๋ฏธํ 2,000๋ฌ๋ฌ์
๋๋ค.<br><br>์ด ๋์ ์ฌ๋ฌ๋ถ์ด ์ด ์๊ฐ๊ณผ ํ ํฐ์ ๋ํ ๋๊ฐ๊ฐ ๋๊ธฐ์๋ ํฑ์์ด ๋ถ์กฑํฉ๋๋ค. ๊ทธ๋ ๊ฒ ๊ณ์ฐํ ์๊ฐ๋ ์์ต๋๋ค. <b>์ด๊ฒ์ โ๋น์ ์ด ํ ์ผ์ ๊ฐ์ด ์์๋คโ๊ณ ๋งํ๋ ๋ฐฉ์์
๋๋ค.</b><br><br>์์ธ์งํ ์ฐ๊ตฌ๊ฐ ํ๋ ์ด์ ๋ ์๋ฌด๋ ๊ณ ๋ง๋ค๊ณ ํ์ง ์๊ธฐ ๋๋ฌธ์
๋๋ค. ๋
ผ๋ฌธ๋ ์ ์ ์ค๋ฆฌ๊ณ , ํฌ์๋ ์ ๋ถ๊ณ , ์๋ฌด๋ ๋ณด์ง ์์ต๋๋ค. ์ด ๋ํ๋ ์ต์ํ ๋๊ฐ ๋ฌด์์ ๊ธฐ์ฌํ๋์ง ๊ธฐ๋ก์ผ๋ก ๋จ๊ธฐ๊ณ , ์์ฆ๋ง๋ค ํ ๋ฒ ๊ฐ์ฌ๋ฅผ ํํฉ๋๋ค."
},
3: {
topic:"์ค๊ฐ์ค๋ณ",
concept:"<b>AI๊ฐ ๋ฐ๊ฒฌํ ์ค๊ฐ์ค๋ณ ์ ์ฝ ํ๋ณด ๋ฌผ์ง</b>์ ๊ฒ์ฆ ๋ฐ ํ๊ฐ",
tagline:"์ด๋ค AI๋ก ์ฐพ์๋ธ ํ๋ณด๋ , ๊ฐ์ ๊ธฐ์ค์ผ๋ก ๊ณ์ฐ ๊ฒ์ฆํ๊ณ ์ ์๋ฅผ ๋งค๊น๋๋ค. ํ์ ์ ์ค๊ฐ์ค๋ณ ์์ถฉ์ด ์ธํฌ๋ง ์คํ
๋กค์ ๋ง๋๋ ๋ฐ ์ฐ๋ ํจ์ CYP51์ด๋ฉฐ, ์ฌ๋์ ๊ฐ์ ํจ์(CYP51A1)๋ ๊ฑด๋๋ฆฌ์ง ์์์ผ ํฉ๋๋ค.",
why:"<b>์ค๊ฐ์ค๋ณ์ ์ค๋จ๋ฏธ๋ฅผ ์ค์ฌ์ผ๋ก ์ฝ 600๋ง ๋ช
์ด ์๊ณ ์์ต๋๋ค</b>(WHO). ๋๋ถ๋ถ ์ค๋ ์ธ์ ์ฆ์ ์์ด ์ง๋ด๋ค๊ฐ ์ฌ์ฅ์ด๋ ์ํ๊ธฐ๊ฐ ์์ํ ๋ง๊ฐ์ง๋๋ค.<br><br>์น๋ฃ์ ๋ <b>60๋
๋ ๋ ๊ฐ์ง๋ฟ</b>์
๋๋ค. ๋ฒค์ฆ๋๋ค์กธ๊ณผ ๋ํธ๋ฅดํฐ๋ชฉ์ค ๋ชจ๋ ๋ถ์์ฉ์ด ์ฌํด ์๋น์ ํ์๊ฐ ๋ณต์ฉ์ ์ค๋จํ๊ณ , ๋ง์ฑ๊ธฐ์๋ ํจ๊ณผ๋ ๋ถํ์คํฉ๋๋ค.<br><br>์ ์ฝ์ด ๋์ค์ง ์๋ ์ด์ ๋ ๊ณผํ์ด ๋งํ์๊ฐ ์๋๋๋ค. ํ์ ๋๋ถ๋ถ์ด ๊ฐ๋ํ ์ง์ญ์ ์์ด ์์ฅ์ด ์ฑ๋ฆฝํ์ง ์๊ธฐ ๋๋ฌธ์
๋๋ค. WHO๊ฐ ์ง์ ํ ์์ธ์ด๋์งํ์ ๋ํ ์ฌ๋ก์
๋๋ค.",
s1_p:"OpenAI ยท Claude ยท Gemini ยท Qwen ยท KIMI ยท DeepSeek ๋ฑ ์ด๋ค ๋ชจ๋ธ์ด๋ , ์ด๋ค ํ๋ค์ค๋ ์์ ์
๋๋ค. ์ง์ ์ค๊ณํด๋ ๋ฉ๋๋ค. ์ค๊ฐ์ค๋ณ ์์ถฉ์ ํจ์ CYP51์ ๋ง์ ์ ๋ถ์๋ฅผ ์ฐพ์ผ์ธ์.",
ov_pf:"์์ถฉ ํจ์", ov_hs:"์ฌ๋ ํจ์",
g1_lead:"์ค๊ฐ์ค๋ณ ์์ถฉ์ ์ธํฌ๋ง์ ํ์ํ ์คํ
๋กค์ ๋ง๋ค ๋ <b>CYP51</b>์ด๋ผ๋ ํจ์๋ฅผ ์๋๋ค. ์ด ํจ์๋ฅผ ๋ง์ผ๋ฉด ์์ถฉ์ด ์ด์๋จ์ง ๋ชปํฉ๋๋ค. ๋ฌธ์ ๋ ์ฌ๋์๊ฒ๋ <b>๊ฐ์ ์ด๋ฆ์ ๊ฐ์ ํจ์</b>๊ฐ ์๋ค๋ ๊ฒ์
๋๋ค.",
g1_a:"T. cruzi CYP51 โ ์์ถฉ์ ์คํ
๋กค 14ฮฑ-ํ๋ฉํธํํจ์. ์์กธ๊ณ ์ฝ๋ฌผ์ด ์ค์ ๋ก ์์ฉํ๋ ์๋ฆฌ์
๋๋ค.",
g1_b:"์ฌ๋ CYP51A1 โ ๊ฐ์ ํจ์. ์์กธ๊ณ ํญ์ง๊ท ์ ์ ๋ถ์์ฉ์ด ์ฌ๊ธฐ์ ๋์ต๋๋ค.",
g1_c:"์์ถฉ์ ์์ฃผ ์ธํฌ ์์, ํนํ ์ฌ๊ทผ ์ธํฌ ์์ ์๋ง์คํฐ๊ณ ํธ ํํ๋ก ์ฝ๋๋ค. ์์ฃผ ์ธํฌ๋ง๊ณผ ์์ถฉ๋ง์ ์ฐจ๋ก๋ก ํต๊ณผํด์ผ ํ์ ์ ๋ฟ์ต๋๋ค.",
cd_label:"์์ฆ #3 ๋ง๊ฐ๊น์ง", cd_over_label:"์์ฆ #3 ๋ง๊ฐ",
prize_amt:"$1,000",
prize_body:"๊ฐ ์์ฆ์ด ๋๋ ๋ <b>์์ํ 1์์๊ฒ ์๊ธ์ ๋๋ฆฝ๋๋ค.</b> ์์ฆ #3(์ค๊ฐ์ค๋ณ)์ <b>2026๋
11์ 30์ผ</b> ๋ง๊ฐ์ด๋ฉฐ ์๊ธ์ ๋ฏธํ 1,000๋ฌ๋ฌ์
๋๋ค.<br><br>์ด ๋์ ์ฌ๋ฌ๋ถ์ด ์ด ์๊ฐ๊ณผ ํ ํฐ์ ๋ํ ๋๊ฐ๊ฐ ๋๊ธฐ์๋ ํฑ์์ด ๋ถ์กฑํฉ๋๋ค. ๊ทธ๋ ๊ฒ ๊ณ์ฐํ ์๊ฐ๋ ์์ต๋๋ค. <b>์ด๊ฒ์ โ๋น์ ์ด ํ ์ผ์ ๊ฐ์ด ์์๋คโ๊ณ ๋งํ๋ ๋ฐฉ์์
๋๋ค.</b><br><br>์์ธ์งํ ์ฐ๊ตฌ๊ฐ ํ๋ ์ด์ ๋ ์๋ฌด๋ ๊ณ ๋ง๋ค๊ณ ํ์ง ์๊ธฐ ๋๋ฌธ์
๋๋ค. ๋
ผ๋ฌธ๋ ์ ์ ์ค๋ฆฌ๊ณ , ํฌ์๋ ์ ๋ถ๊ณ , ์๋ฌด๋ ๋ณด์ง ์์ต๋๋ค. ์ด ๋ํ๋ ์ต์ํ ๋๊ฐ ๋ฌด์์ ๊ธฐ์ฌํ๋์ง ๊ธฐ๋ก์ผ๋ก ๋จ๊ธฐ๊ณ , ์์ฆ๋ง๋ค ํ ๋ฒ ๊ฐ์ฌ๋ฅผ ํํฉ๋๋ค."
},
4: {
topic:"๋น๋ง์ฝ์ฑ ์งํต",
concept:"<b>AI๊ฐ ๋ฐ๊ฒฌํ ๋น๋ง์ฝ์ฑ ์งํต์ ํ๋ณด ๋ฌผ์ง</b>์ ๊ฒ์ฆ ๋ฐ ํ๊ฐ",
tagline:"์ด๋ค AI๋ก ์ฐพ์๋ธ ํ๋ณด๋ , ๊ฐ์ ๊ธฐ์ค์ผ๋ก ๊ณ์ฐ ๊ฒ์ฆํ๊ณ ์ ์๋ฅผ ๋งค๊น๋๋ค. ํ์ ์ ํต์ฆ ์ ํธ๋ฅผ ๋๋ฅด๋ ๋ํธ๋ฅจ ์ฑ๋ Nav1.7์ด๋ฉฐ, ์ฌ์ฅ ๋ฐ๋์ ์กฐ์ ํ๋ hERG ์ฑ๋์ ๊ฑด๋๋ฆฌ์ง ์์์ผ ํฉ๋๋ค.",
why:"<b>WHO๋ 2023๋
๋ณด๊ณ ์์ ์ ๋ชฉ์ ใํต์ฆ ์์ ๋จ๊ฒจ์ง ์ฌ๋๋คใ์ด๋ผ๊ณ ๋ถ์์ต๋๋ค.</b><br><br>๊ฐ์ ์ฝ์ด ์ธ์์ ํ์ชฝ์์๋ ๋์ณ์ ์ฌ๋์ ์ฃฝ์ด๊ณ , ๋ค๋ฅธ ํ์ชฝ์์๋ ์์ด์ ์ฌ๋์ ๊ณ ํต ์์ ์ฃฝ๊ฒ ํฉ๋๋ค.<br><br><b>๋์น๋ ์ชฝ.</b> WHO ์ถ์ฐ์ผ๋ก 2019๋
์ฝ๋ฌผ๋ก ์ธํ ์ฌ๋ง ์ฝ 60๋ง ๋ช
๊ฐ์ด๋ฐ 80%๊ฐ ์คํผ์ค์ด๋์ ๊ด๋ จ๋์ด ์์ต๋๋ค. 2021๋
์ฝ 6,000๋ง ๋ช
์ด ์คํผ์ค์ด๋๋ฅผ ์ฌ์ฉํ๊ณ , ์์กด ์น๋ฃ๊ฐ ํ์ํ ์ฌ๋ ์ค ์ค์ ๋ก ์น๋ฃ๋ฐ๋ ์ฌ๋์ 10%์ ๋ฏธ์น์ง ๋ชปํฉ๋๋ค.<br><br><b>์๋ ์ชฝ.</b> ๊ฐ์ WHO ๋ณด๊ณ ์๋ ๊ณ ์๋๊ตญ๊ณผ ์ ์๋๊ตญ์ ๋ชจ๋ฅดํ ์ฌ์ฉ๋ ์ฐจ์ด๊ฐ <b>5๋ฐฐ์์ 63๋ฐฐ</b>์ ์ด๋ฅธ๋ค๊ณ ์ ์์ต๋๋ค. ๊ฐ์ฅ ๋ถ์ ํ 10% ๊ตญ๊ฐ๊ฐ ์ ํต๋๋ ๋ชจ๋ฅดํ์ 90%๋ฅผ ์๋๋ค. ๋๋จธ์ง ์ฌ๋๋ค์ ์์ ๋ค์๋, ๋ง๊ธฐ ์์๋ ์งํต์ ์์ด ๊ฒฌ๋ฅ๋๋ค.<br><br>๋ ๋ฌธ์ ์ ๋ต์ ํ๋์
๋๋ค. <b>์์กด์ฑ ์๋ ์งํต์ .</b> ๊ทธ๊ฒ์ด ์์ผ๋ฉด ๋์น๋ ์ชฝ์ ๋ ์ฃฝ๊ณ , ์๋ ์ชฝ์ ๋ง์ฝ ๊ท์ ์ ๋ฌถ์ด์ง ์๊ณ ์ธ ์ ์์ต๋๋ค.<br><br>Nav1.7์ ๊ทธ ๋ต์ ๊ฐ์ฅ ๊ฐ๊น์ด ๊ฐ ํ์ ์
๋๋ค. ์ด ์ฑ๋์ด ์๋ํ์ง ์๋ ์ ์ ์๋ฅผ ๊ฐ์ง ์ฌ๋๋ค์ <b>ํต์ฆ์ ๋๋ผ์ง ์์ผ๋ฉด์ ๋ค๋ฅธ ๊ฐ๊ฐ์ ์ ์</b>์
๋๋ค. ๋๋ฌผ์ด ์๋๋ผ ์ฌ๋์ด ์ง์ ์ฆ๋ช
ํด ์ค ํ์ ์
๋๋ค.<br><br>๊ทธ๋ฐ๋ฐ๋ ์์ง ์ฝ์ด ์์ต๋๋ค. ์ด๋ ค์์ ํ์ ์ด ์๋๋ผ <b>๊ตฌ๋ถ</b>์ ์์ต๋๋ค. ๋ชธ์๋ ๋น์ทํ ๋ํธ๋ฅจ ์ฑ๋์ด ์ฌ๋ฟ ์๊ณ , ์ฌ์ฅ์ hERG ์ฑ๋์ ํจ๊ป ๋ง์ผ๋ฉด ๋ถ์ ๋งฅ์ผ๋ก ์ฌ๋์ด ์ฃฝ์ต๋๋ค. ์ฌ๋ฌ ํ๋ณด๊ฐ ๊ทธ ์ด์ ๋ก ๊ฐ๋ฐ์ด ์ค๋จ๋์ต๋๋ค.<br><br>์ด ์์ฆ์ด ๋ฌป๋ ๊ฒ์ ํ๋์
๋๋ค. <b>ํต์ฆ ์ฑ๋๋ง ๊ณจ๋ผ ๋ง์ ์ ์๋๊ฐ.</b>",
s1_p:"OpenAI ยท Claude ยท Gemini ยท Qwen ยท KIMI ยท DeepSeek ๋ฑ ์ด๋ค ๋ชจ๋ธ์ด๋ , ์ด๋ค ํ๋ค์ค๋ ์์ ์
๋๋ค. ์ง์ ์ค๊ณํด๋ ๋ฉ๋๋ค. ํต์ฆ ์ ํธ๋ฅผ ๋๋ฅด๋ ๋ํธ๋ฅจ ์ฑ๋ Nav1.7์ ๋ง๋ ์ฌ์ฅ ์ฑ๋์ ๊ฑด๋๋ฆฌ์ง ์๋ ์ ๋ถ์๋ฅผ ์ฐพ์ผ์ธ์.",
ov_pf:"ํต์ฆ ์ฑ๋", ov_hs:"์ฌ์ฅ ์ฑ๋",
g1_lead:"ํต์ฆ ์ ํธ๋ ์ ๊ฒฝ์์ <b>๋ํธ๋ฅจ ์ฑ๋</b>์ ํตํด ์ ๋ฌ๋ฉ๋๋ค. ๊ทธ์ค <b>Nav1.7</b>์ ํต์ฆ ์ ๊ฒฝ์ ์ง์ค์ ์ผ๋ก ์์ด ์ด๊ฒ๋ง ๋ง์ผ๋ฉด ํต์ฆ๋ง ์ค์ผ ์ ์์ต๋๋ค. ๋ฌธ์ ๋ ๋ชธ์ ๋น์ทํ ์ฑ๋์ด ์ฌ๋ฟ ์๊ณ , ํนํ <b>์ฌ์ฅ ์ฑ๋์ ํจ๊ป ๋ง์ผ๋ฉด ์ํํ๋ค</b>๋ ๊ฒ์
๋๋ค.",
g1_a:"Nav1.7 VSD4 โ ๋๋ฉ์ธ IV ์ ์์ผ์. ์ด ๊ณ์ด ์ ํด์ ๊ฐ ์ค์ ๋ก ๋ถ๋ ์๋ฆฌ์
๋๋ค. ์ฑ๋ ์ ์ฒด๊ฐ ์๋๋ผ ์ด ๊ตฌ๊ฐ์ ์๋๋ค.",
g1_b:"hERG ๊ณต๊ทน โ ์ฌ์ฅ ์ฌ๋ถ๊ทน์ ๋ด๋นํ๋ ์นผ๋ฅจ ์ฑ๋. ์ฌ๊ธฐ๋ฅผ ๋ง์ผ๋ฉด ๋ถ์ ๋งฅ ์ํ์ด ์๊น๋๋ค. ๋ค ๊ฐ ์๋จ์๊ฐ ๋ชจ์ฌ ์ฝ๋ฌผ์ด ๋ค์ด๊ฐ๋ ๊ณต๊ฐ์ ๋ง๋ค๊ธฐ ๋๋ฌธ์ <b>4๋์ฒด๋ก</b> ๊ณ์ฐํฉ๋๋ค.",
g1_c:"์งํต์ ๋ ํต์ฆ์ด ์๊ธฐ๋ ๊ณณ๊น์ง ๋ฟ์์ผ ํ๋ฏ๋ก ๋์ฒด๋ก ์๊ณ ๊ฐ๋ณ์ต๋๋ค. ์ด ์์ฆ์ ํฌ๊ธฐ ํ๋๊ฐ ์ด์ ์์ฆ๋ณด๋ค ๋ฎ์ ์ด์ ์
๋๋ค.",
cd_label:"์์ฆ #4 ๋ง๊ฐ๊น์ง", cd_over_label:"์์ฆ #4 ๋ง๊ฐ",
prize_amt:"$1,000",
prize_body:"๊ฐ ์์ฆ์ด ๋๋ ๋ <b>์์ํ 1์์๊ฒ ์๊ธ์ ๋๋ฆฝ๋๋ค.</b> ์์ฆ #4(๋น๋ง์ฝ์ฑ ์งํต)๋ <b>2027๋
1์ 31์ผ</b> ๋ง๊ฐ์ด๋ฉฐ ์๊ธ์ ๋ฏธํ 1,000๋ฌ๋ฌ์
๋๋ค.<br><br>์ด ๋์ ์ฌ๋ฌ๋ถ์ด ์ด ์๊ฐ๊ณผ ํ ํฐ์ ๋ํ ๋๊ฐ๊ฐ ๋๊ธฐ์๋ ํฑ์์ด ๋ถ์กฑํฉ๋๋ค. ๊ทธ๋ ๊ฒ ๊ณ์ฐํ ์๊ฐ๋ ์์ต๋๋ค. <b>์ด๊ฒ์ โ๋น์ ์ด ํ ์ผ์ ๊ฐ์ด ์์๋คโ๊ณ ๋งํ๋ ๋ฐฉ์์
๋๋ค.</b><br><br>ํต์ฆ์ ํํ ๋ฌธ์ ์ง๋ง, ์คํผ์ค์ด๋๋ฅผ ๋์ ํ ์ฝ์ ์ฐพ๋ ์ผ์ ์ค๋ ๋งํ ์์์ต๋๋ค. ์ด ๋ํ๋ ์ต์ํ ๋๊ฐ ๋ฌด์์ ๊ธฐ์ฌํ๋์ง ๊ธฐ๋ก์ผ๋ก ๋จ๊ธฐ๊ณ , ์์ฆ๋ง๋ค ํ ๋ฒ ๊ฐ์ฌ๋ฅผ ํํฉ๋๋ค."
}
},
en: {
1: {
topic:"Malaria",
concept:"<b>Verifying and scoring malaria drug candidates discovered by AI</b>",
tagline:"However you found the candidate, it is checked computationally against the same rubric and scored. The target is PfDHODH, an enzyme the malaria parasite depends on; the human counterpart must be left alone.",
s1_p:"OpenAI, Claude, Gemini, Qwen, KIMI, DeepSeek - any model, any harness, or by hand. The goal is a small molecule that blocks PfDHODH, an enzyme the malaria parasite depends on.",
ov_pf:"parasite enzyme", ov_hs:"human enzyme",
g1_lead:"The malaria parasite depends on an enzyme called <b>PfDHODH</b> to survive. Block it and the parasite dies. The difficulty is that humans carry an enzyme of the same family.",
g1_a:"PfDHODH - the parasite's enzyme, which it cannot live without.",
g1_b:"Human DHODH - same family. Blocking it is immunosuppression, not treatment.",
cd_label:"Season #1 closes in", cd_over_label:"Season #1 closed",
prize_amt:"$1,000",
prize_body:"When a season closes, <b>the entry at the top of the table receives a prize.</b> Season #1 (Malaria) closes on <b>30 September 2026</b> and carries USD 1,000.<br><br>This does not come close to paying for the time and tokens you spent, and it is not meant to. <b>It is a way of saying that what you did had worth.</b><br><br>Neglected-disease work is thankless by construction: the papers are hard to place, the funding is not there, and mostly nobody looks. This challenge at least records who contributed what, and says thank you once a season."
},
2: {
topic:"Tuberculosis",
concept:"<b>Verifying and scoring tuberculosis drug candidates discovered by AI</b>",
tagline:"However you found the candidate, it is checked computationally against the same rubric and scored. The target is InhA, the enzyme M. tuberculosis uses to build its cell wall; the human enzyme that does the same chemistry must be left alone.",
why:"<b>Tuberculosis kills about 1.25 million people a year - more than any other single infection</b> (WHO Global TB Report 2024). Treatment exists. It also takes <b>six months of daily doses</b>, and resistant strains that shrug it off keep spreading. Patients with multidrug-resistant TB take drugs for over a year and close to half of them still are not cured.<br><br>New tuberculosis drugs are rare not because the science is stuck but because most patients are poor and there is no market. Forty years passed without a single new one before bedaquiline was approved in 2012.<br><br>Season #2 aims at that gap. <b>Bring what your AI found; it is verified computationally and ranked on the same scale as everyone else's.</b>",
s1_p:"OpenAI, Claude, Gemini, Qwen, KIMI, DeepSeek - any model, any harness, or by hand. The goal is a small molecule that blocks InhA, an enzyme M. tuberculosis depends on.",
ov_pf:"bacterial enzyme", ov_hs:"human enzyme",
g1_lead:"M. tuberculosis uses an enzyme called <b>InhA</b> to build the fatty acids in its cell wall. It is what isoniazid, the front-line tuberculosis drug, actually blocks. The difficulty is that humans run the same chemistry.",
g1_a:"InhA - the bacterium's enoyl reductase, where isoniazid and ethionamide act.",
g1_b:"The enoyl-reductase domain of human FASN - same chemistry. Blocking it stops our own fatty-acid synthesis.",
g1_c:"M. tuberculosis is wrapped in a waxy mycolic-acid wall, far less permeable than most bacteria, and it effluxes actively.",
cd_label:"Season #2 closes in", cd_over_label:"Season #2 closed",
prize_amt:"$2,000",
prize_body:"When a season closes, <b>the entry at the top of the table receives a prize.</b> Season #2 (Tuberculosis) closes on <b>31 October 2026</b> and carries USD 2,000.<br><br>This does not come close to paying for the time and tokens you spent, and it is not meant to. <b>It is a way of saying that what you did had worth.</b><br><br>Neglected-disease work is thankless by construction: the papers are hard to place, the funding is not there, and mostly nobody looks. This challenge at least records who contributed what, and says thank you once a season."
},
3: {
topic:"Chagas disease",
concept:"<b>Verifying and scoring Chagas disease drug candidates discovered by AI</b>",
tagline:"However you found the candidate, it is checked computationally against the same rubric and scored. The target is CYP51, the enzyme T. cruzi uses to build its membrane sterols; the human enzyme of the same name must be left alone.",
why:"<b>Chagas disease affects around 6 million people, mostly in Latin America</b> (WHO). Many carry it for decades without symptoms while the heart or gut is slowly damaged.<br><br>There are <b>two drugs, both sixty years old</b>. Benznidazole and nifurtimox are hard enough to tolerate that many patients stop taking them, and their effect in the chronic stage is uncertain.<br><br>No new drug has arrived, not because the science is stuck but because the patients are poor and there is no market. It is the archetype of a WHO neglected tropical disease.",
s1_p:"OpenAI, Claude, Gemini, Qwen, KIMI, DeepSeek - any model, any harness, or by hand. The goal is a small molecule that blocks CYP51, an enzyme T. cruzi depends on.",
ov_pf:"parasite enzyme", ov_hs:"human enzyme",
g1_lead:"T. cruzi uses an enzyme called <b>CYP51</b> to make the sterols its membranes need. Block it and the parasite cannot survive. The difficulty is that humans carry <b>an enzyme of the same name doing the same job</b>.",
g1_a:"T. cruzi CYP51 - the parasite's sterol 14a-demethylase, where the azole drugs act.",
g1_b:"Human CYP51A1 - the same enzyme. Azole antifungal side effects come from inhibiting it.",
g1_c:"The parasite persists inside host cells as an amastigote, most importantly in cardiac muscle. Your compound has to cross the host cell membrane and then the parasite's.",
cd_label:"Season #3 closes in", cd_over_label:"Season #3 closed",
prize_amt:"$1,000",
prize_body:"When a season closes, <b>the entry at the top of the table receives a prize.</b> Season #3 (Chagas disease) closes on <b>30 November 2026</b> and carries USD 1,000.<br><br>This does not come close to paying for the time and tokens you spent, and it is not meant to. <b>It is a way of saying that what you did had worth.</b><br><br>Neglected-disease work is thankless by construction: the papers are hard to place, the funding is not there, and mostly nobody looks. This challenge at least records who contributed what, and says thank you once a season."
},
4: {
topic:"Non-opioid analgesia",
concept:"<b>Verifying and scoring non-opioid analgesic candidates discovered by AI</b>",
tagline:"However you found the candidate, it is checked computationally against the same rubric and scored. The target is Nav1.7, the sodium channel that carries pain signals; the cardiac hERG channel must be left alone.",
why:"<b>WHO titled its 2023 report <i>Left behind in pain</i>.</b><br><br>The same class of drug kills people where it is abundant and leaves people to die in pain where it is absent.<br><br><b>Where there is too much.</b> WHO estimates that of roughly 600,000 deaths attributable to drug use in 2019, about 80% involved opioids. Around 60 million people used opioids in 2021, and fewer than one in ten of those who need treatment for dependence receive it.<br><br><b>Where there is none.</b> The same WHO report records a <b>5- to 63-fold</b> difference in morphine consumption between high-income and lower-income countries. The wealthiest 10% of countries account for 90% of the morphine distributed. Everyone else goes without - after surgery, and in terminal cancer.<br><br>Both problems have one answer. <b>An analgesic that does not create dependence.</b> Where there is excess, fewer people die; where there is none, it can be supplied without narcotic control.<br><br>Nav1.7 is the closest thing to that answer. People carrying loss-of-function variants of this channel <b>feel no pain while their other senses stay intact</b> - a target validated in humans rather than in animals.<br><br>And yet there is still no drug. The difficulty is not the target but <b>telling it apart</b>. The body carries several similar sodium channels, and a compound that also blocks the cardiac hERG channel can kill by arrhythmia. Several programmes stopped for exactly that reason.<br><br>This season asks one question. <b>Can you block the pain channel and only the pain channel?</b>",
s1_p:"OpenAI, Claude, Gemini, Qwen, KIMI, DeepSeek - any model, any harness, or by hand. The goal is a small molecule that blocks Nav1.7, the sodium channel carrying pain signals, while leaving the cardiac channel alone.",
ov_pf:"pain channel", ov_hs:"cardiac channel",
g1_lead:"Pain signals travel along nerves through <b>sodium channels</b>. <b>Nav1.7</b> sits mainly in pain-sensing neurons, so blocking it should reduce pain and little else. The difficulty is that several similar channels exist, and <b>blocking the cardiac one is dangerous</b>.",
g1_a:"Nav1.7 VSD4 - the domain IV voltage sensor, where this inhibitor class actually binds. The season docks this domain rather than the whole channel.",
g1_b:"hERG pore - the potassium channel behind cardiac repolarisation. Blocking it carries arrhythmia risk. Four subunits together form the cavity a drug occupies, so it is modelled as a <b>tetramer</b>.",
g1_c:"An analgesic has to reach where the pain is, so this chemistry runs small and light. That is why this season's size limits are lower than earlier ones.",
cd_label:"Season #4 closes in", cd_over_label:"Season #4 closed",
prize_amt:"$1,000",
prize_body:"When a season closes, <b>the entry at the top of the table receives a prize.</b> Season #4 (Non-opioid analgesia) closes on <b>31 January 2027</b> and carries USD 1,000.<br><br>It is nowhere near payment for the time and tokens you spent, and it is not meant as payment. <b>It is a way of saying the work was worth something.</b><br><br>Pain is ordinary, but finding something to put in place of opioids has been stuck for a long time. This contest at least records who contributed what, and says thank you once a season."
}
}
};
// season copy wins over the shared strings; anything a season does not override is shared
function t(){ return Object.assign({}, T[LANG], (ST[LANG] || {})[SEASON] || {}); }
const submittedDate = e => {
if(e.is_anchor || !e.submitted_at) return "โ";
const locale = LANG === "ko" ? "ko-KR" : "en-CA";
return new Intl.DateTimeFormat(locale, {
timeZone:"Asia/Seoul", year:"numeric", month:"2-digit", day:"2-digit"
}).format(new Date(Number(e.submitted_at) * 1000));
};
// Seasons can carry an intro clip. It is written into the page only for the season it
// belongs to - emptied rather than hidden - so a reader on another season never fetches
// the file. Muted and inline because autoplay with sound is blocked everywhere; the clip
// has no audio track, so nothing is lost.
const SEASON_INTRO = {2: "assets/season2-intro.mp4"};
function renderIntro(){
const src = SEASON_INTRO[SEASON], box = $("#intro");
// clearing the marker as well as the markup: leaving it set made a return to this
// season look like "already playing" and the slot stayed empty
if(!src){ box.innerHTML = ""; delete box.dataset.src; return; }
const cred = t().intro_credit || "";
if(box.dataset.src === src && box.querySelector("video")){
// the clip is already playing; only the wording can have changed, and rewriting the
// whole block would restart the video every time the language is switched
const c = box.querySelector(".credit");
if(c) c.textContent = cred;
return;
}
box.dataset.src = src;
box.innerHTML = `<video src="${src}" autoplay loop muted playsinline preload="metadata"></video>`
+ (cred ? `<div class="credit">${cred}</div>` : "");
}
// Cumulative submissions per season. Its own timer, ten minutes apart: the board itself
// reloads every twenty seconds and this number does not move that fast.
let TALLY = null;
async function loadTally(){
if(!SEASONS) return;
try{
const rs = await Promise.all(SEASONS.map(x =>
fetch("api/queue?season=" + x.number).then(r => r.json())));
TALLY = SEASONS.map((x, i) => ({n: x.number, total: rs[i].total}))
.sort((a, b) => b.n - a.n);
renderTally();
}catch(_){ /* leave the previous figure up rather than blanking it */ }
}
function renderTally(){
if(!TALLY) return;
const d = t();
$("#tally").innerHTML = TALLY.map(x =>
`<div class="t"><b>${x.total.toLocaleString()}</b>`
+ `<span>#${x.n} ${d.tally_label}</span></div>`).join("");
}
function renderSeasonBar(){
if(!SEASONS) return;
const d = t();
// newest season first: the one people are entering now should be the one they reach first
$("#seasonbar").innerHTML = SEASONS.slice().sort((a,b)=>b.number-a.number).map(s => {
const nm = (ST[LANG] && ST[LANG][s.number] && ST[LANG][s.number].topic) || s.topic;
// a season that is not taking entries says so on the button, so nobody clicks
// through and writes out a molecule before finding out
const tag = s.open ? "" : `<span class="st">${d.season_soon}</span>`;
return `<button data-season="${s.number}" class="${s.number===SEASON?"on":""}">`
+ `#${s.number} ${nm}${tag}</button>`;
}).join("");
document.querySelectorAll("#seasonbar button").forEach(b =>
b.onclick = () => setSeason(parseInt(b.dataset.season,10)));
}
function setSeason(n){
if(n === SEASON) return;
SEASON = n;
page = 0; // a new season starts at its own first page
localStorage.setItem("odc_season", String(n));
// the season belongs in the URL: a link to a season should open on that season
const u = new URL(location.href); u.searchParams.set("season", String(n));
history.replaceState(null, "", u);
DATA = null; MODELS = {models:[],totals:{models:0,submissions:0}};
$("#rows").innerHTML = "";
applyLang(); load();
}
function applyLang(){
const d = t();
document.documentElement.lang = LANG;
{ const x = $("#xlink"); if(x && d.xlink) x.innerHTML = d.xlink;
const x2 = $("#xlink2"); if(x2 && d.xlink2) x2.innerHTML = d.xlink2; }
document.querySelectorAll("[data-i18n]").forEach(el=>{
const v = d[el.dataset.i18n]; if(v) el.textContent = v;
});
$("#concept").innerHTML = d.concept;
["ge_lead","ge_proof","ge_caveat"].forEach(k => { const el=$("#"+k); if(el) el.innerHTML = d[k]; });
["ge_p_list","ge_c_list"].forEach(k => { const el=$("#"+k);
if(el) el.innerHTML = (d[k]||[]).map(x => `<li>${x}</li>`).join(""); });
const gb = $("#ge_boards");
if(gb) gb.innerHTML = BOARDS.map(b => `<span>${b}</span>`).join("");
// the rubric and the size cap are stated by the page but owned by the scorer, so they
// are substituted from the season rather than written into the copy pack. Two of the
// three seasons were showing season 1's numbers before this.
["g1_lead","g2_lead","g3_lead","g4_lead"].forEach(k => { const el=$("#"+k); if(el) el.innerHTML = fillFacts(d[k]); });
renderPrompts(); renderFails();
$("#prize_body").innerHTML = d.prize_body;
$("#prize_fine").innerHTML = d.prize_fine;
$("#own_keep").innerHTML = d.own_keep;
$("#own_body").innerHTML = d.own_body;
$("#own_warn").innerHTML = d.own_warn;
$("#why").innerHTML = d.why;
$("#boardnote").innerHTML = d.boardnote;
$("#formnote").innerHTML = d.formnote + (d.daily_cap ? "<br><b>" + d.daily_cap + "</b>" : "");
$("#display_name").placeholder = LANG==="ko" ? "๊ณต๊ฐ ์์ํ์ ํ์๋ฉ๋๋ค" : "shown on the public table";
$("#rationale").placeholder = LANG==="ko" ? "์ ์ด ๊ตฌ์กฐ์ธ์ง ๊ฐ๋จํ" : "why this structure, briefly";
document.querySelectorAll("#langbar button").forEach(b=>b.classList.toggle("on", b.dataset.lang===LANG));
$("#langnote").textContent = LANG_AUTO ? d.auto : d.manual;
const si = seasonInfo();
if(si){
$("#seasonhead").innerHTML = `#${si.number} <em>${d.topic}</em>`;
document.title = `Open Discovery Challenge #${si.number} ${d.topic}`;
}
if(d.prize_amt) $("#prize_amt").firstChild.nodeValue = d.prize_amt + " ";
// ๋์ ์ด ์๊ธ์ ์์ฆ ๋ชฉ๋ก์์ ๋ํ๋ค. ์์ผ๋ก ์ ์ผ๋ฉด ์์ฆ์ด ํ๋ ๋ ๋๋ง๋ค ํ๋ฆฐ๋ค -
// ๋ถ๋ฌธ ํ๋๋ฅผ ์ฐ๋ฌธ์ผ๋ก ์ ์๋ค๊ฐ 550 ์ด 750 ์ด ๋ ๋ค์๋ ๊ทธ๋๋ก ๋จ์ ์๋ ์ ์ด ์๋ค.
{ const el = $("#prize_total");
if(el && SEASONS){
const tot = SEASONS.reduce((a,s)=>a+(s.prize_usd||0),0);
el.textContent = d.prize_total_label
? d.prize_total_label(tot.toLocaleString(), SEASONS.length) : "";
} }
renderSeasonBar();
renderIntro();
renderTally();
renderAuth();
tickCountdown();
if(DATA) render();
renderModels(MODELS);
}
function setLang(l, auto){ LANG = (l==="ko")?"ko":"en"; if(!auto) LANG_AUTO=false; applyLang(); }
document.querySelectorAll("#langbar button").forEach(b=>b.onclick=()=>setLang(b.dataset.lang,false));
function sortVal(e, k){
if(k==="rank") return e.rank ?? 1e9; // unranked rows sink when sorting by rank
if(k==="cand") return String(e.candidate_id||"").toLowerCase();
if(k==="user") return String(e.hf_user||e.display_name||"").toLowerCase();
if(k==="who") return String(e.model_name||"").toLowerCase();
if(k==="date") return e.submitted_at ?? 0;
if(k==="total") return e.total ?? -1;
return (e.axes||{})[k] ?? -1;
}
function esc(s){
return String(s ?? "").replace(/[&<>"']/g, c=>({
"&":"&", "<":"<", ">":">", '"':""", "'":"'"
})[c]);
}
function hfProfile(user){
if(!user) return "";
const label = esc(user);
const url = `https://huggingface.co/${encodeURIComponent(user)}`;
return `<a class="hf-user" href="${url}" target="_blank" rel="noopener noreferrer"`
+ ` title="Hugging Face: ${label}">๐ค ${label}</a>`;
}
function renderPager(total, pages){
const host = $("#pager"), d = t();
if(pages <= 1){ host.innerHTML = ""; return; }
const from = page * PAGE_SIZE + 1;
const to = Math.min(total, (page + 1) * PAGE_SIZE);
// Every page number, once there are few enough to read; otherwise the ends, the
// current neighbourhood, and gaps for the rest.
let nums = [];
if(pages <= 9){ for(let i=0;i<pages;i++) nums.push(i); }
else {
const near = [page-1, page, page+1].filter(i => i>0 && i<pages-1);
nums = [0, ...near, pages-1];
nums = [...new Set(nums)].sort((a,b)=>a-b);
}
let out = `<button ${page===0?"disabled":""} data-p="${page-1}">โน</button>`;
let prev = -1;
for(const i of nums){
if(i - prev > 1) out += `<span class="gap">โฆ</span>`;
out += `<button class="${i===page?"on":""}" data-p="${i}">${i+1}</button>`;
prev = i;
}
out += `<button ${page>=pages-1?"disabled":""} data-p="${page+1}">โบ</button>`;
out += `<span class="pinfo">${d.prange(from, to, total)}</span>`;
host.innerHTML = out;
host.querySelectorAll("button[data-p]").forEach(b => b.onclick = () => {
if(b.disabled) return;
page = parseInt(b.dataset.p, 10);
render();
// Land at the top of the table, not wherever the previous page left the scroll.
const c = document.querySelector(".card .scroll");
if(c) window.scrollTo({top: c.getBoundingClientRect().top + window.scrollY - 80,
behavior: "smooth"});
});
}
function render(){
const d = t(), W = DATA.season.weights, max = Math.max(1, ...DATA.entries.map(e=>e.total||0));
$("#wts").innerHTML = Object.entries(W)
.map(([k,v])=>`<span>${(d.ov_axes[k]||k)} <b>${v}</b></span>`).join("");
$("#counts").textContent = d.counts(DATA.counts.scored, DATA.counts.anchors);
$("#head").innerHTML = COLS.map(k=>{
const on = sortKey===k;
const ar = on ? (sortDir<0 ? "โผ" : "โฒ") : "โพ";
return `<th data-k="${k}" class="${on?"sorted":""}">${d.cols[k]}<span class="ar">${ar}</span></th>`;
}).join("");
document.querySelectorAll("#head th").forEach(th=>th.onclick=()=>{
const k = th.dataset.k;
if(sortKey===k) sortDir = -sortDir;
else { sortKey = k; sortDir = (k==="rank"||k==="cand"||k==="who") ? 1 : -1; }
page = 0; // a new sort means a different first page
render();
});
const all = DATA.entries.slice().sort((a,b)=>{
// ๊ฐ๋ฑ ํญ๋ชฉ์ ์์์์ ๋น ์ก๋๋ฐ ์ด์ ์ด ๋์ผ๋ฉด 1์ ์์ ๋ด๋ค. ์์์นธ์ด "โ" ์ฌ๋
// ๋งจ ์์ค์ ์ต๊ณ ์ ์ผ๋ก ์ฝ๊ฒ ๋๋ค. ์ ์์ ๋ฑ์๋ ๊ทธ๋๋ก ๋๊ณ ์๋ฆฌ๋ง ์์๊ถ ์๋๋ก
// ๋ด๋ฆฐ๋ค. ๊ธฐ์ค๋ฌผ์ง์ ๋ด๋ฆฌ์ง ์๋๋ค - ์น์ธ์ฝ ๋๋น ์์น๋ฅผ ๋ณด๋ผ๊ณ ์์ด ๋ ๊ฒ์ด๋ค.
const ra = a.tier===2, rb = b.tier===2;
if(ra !== rb) return ra ? 1 : -1;
const x = sortVal(a,sortKey), y = sortVal(b,sortKey);
if(x<y) return -sortDir; if(x>y) return sortDir; return 0;
});
// Clamp before slicing: switching to a shorter season while deep in the pages of a
// longer one would otherwise land on an empty table.
const pages = Math.max(1, Math.ceil(all.length / PAGE_SIZE));
if(page >= pages) page = pages - 1;
if(page < 0) page = 0;
const from = page * PAGE_SIZE;
const rows = all.slice(from, from + PAGE_SIZE);
renderPager(all.length, pages);
$("#rows").innerHTML = rows.length ? rows.map(e=>{
const a = e.axes||{};
const cls = [e.is_anchor?"anchor":"", e.tier===2?"tier2":""].join(" ").trim();
const _who = e.hf_user || e.display_name || "";
const user = e.is_anchor ? '<span class="who">\u2014</span>'
: (e.hf_user ? hfProfile(e.hf_user)
: `<span title="${esc(_who)}">${esc(e.display_name||"\u2013")}</span>`);
const _m = e.is_anchor ? (anchorNote(e) || d.ref) : (e.model_name || "\u2013");
const who = `<span class="who" title="${esc(_m)}">${esc(_m)}</span>`;
// the structure is the name now; a withheld one shows its ends, middle blanked.
// Only a published structure gets a copy button - there is nothing to copy otherwise.
const isPub = e.visibility === "public" && !!e.smiles;
const shown = isPub ? e.smiles : e.smiles_masked;
const clip = shown ? (shown.length > 26 ? shown.slice(0, 26) + "\u2026" : shown) : "";
const id = e.is_anchor ? `<b>${e.candidate_id}</b>`
: (shown
? `<span class="smiwrap"><span class="smi2" title="${shown}">${clip}</span>`
+ (isPub ? `<button class="d3" data-smi="${e.smiles}" title="${d.view_3d}">3D</button>`
+ `<button class="cp" data-smi="${e.smiles}" title="${d.copy_smiles}">\u29c9</button>` : "")
+ `</span>`
: `<span class="cid">${e.candidate_id}</span>`);
const tag = e.is_anchor ? `<span class="tag a">${d.anchor}</span>`
: (e.tier===2 ? `<span class="tag r">${d.relegated}</span>` : "");
// ๋ฐ์์ฑ ๊ฒฝ๋ณด. ํ๊ฒฐ์ด ์๋๋ผ ์ฌ์ค์ด๋ฏ๋ก ๋ฑ์๋ฅผ ๊น์ง ์๊ณ ์์ ์ ๊ธฐ๋ง ํ๋ค.
const alr = (e.alerts && e.alerts.length)
? `<span class="tag w" title="${e.alerts.join(", ")}">${d.reactive}</span>` : "";
// ์ด์ ์์ ยฑ. ์ฐ ๊ฐ์๋ ํญ์ด ์๊ณ , ๊ทธ ํญ์ ๊ฐ์ถ๋ฉด ์์๊ฐ ์ค์ ๋ณด๋ค ํ์คํด ๋ณด์ธ๋ค.
const sdTxt = (e.total_sd!=null && e.total_sd>0) ? `<span class="sd">ยฑ${f1(e.total_sd)}</span>` : "";
const rk = e.rank==null ? "โ"
: `#${e.rank}<span class="rkscore">${f3(e.total)}${LANG==="ko"?"์ ":" pts"}${sdTxt}</span>`;
return `<tr class="${cls}">
<td class="rk ${e.rank===1?"top":""}">${rk}</td>
<td>${id}${tag}${alr}</td><td>${user}</td><td>${who}</td><td>${submittedDate(e)}</td>
${AX.map(k=>`<td>${f1(a[k])}</td>`).join("")}
<td><div class="barwrap"><span class="bar"><i style="width:${Math.max(2,(e.total||0)/max*100)}%"></i></span>
<span class="tot">${f3(e.total)}</span></div></td></tr>`;
}).join("") : `<tr><td colspan="12" class="who">${d.empty}</td></tr>`;
wireCopy($("#rows"));
wire3D($("#rows"));
// rows carry their entry so the overlay never has to look anything up again
[...document.querySelectorAll("#rows tr")].forEach((tr, i) => {
const e = rows[i];
if(!e) return;
tr.onmouseenter = () => { clearTimeout(OV._t); showOverlay(e, tr.getBoundingClientRect()); };
// a short grace period, so moving the pointer into the panel does not dismiss it
tr.onmouseleave = () => { OV._t = setTimeout(hideOverlay, 220); };
// touch has no hover, so a tap toggles it
tr.onclick = () => (OV.style.display === "block" && OV.dataset.id === e.candidate_id)
? hideOverlay()
: (OV.dataset.id = e.candidate_id, showOverlay(e, tr.getBoundingClientRect()));
});
}
let ME = {signed_in:false, oauth_configured:false};
let MODELS = {models:[], totals:{models:0, submissions:0}};
function seasonClosed(){
const si = seasonInfo();
return si ? !si.open : false;
}
function renderAuth(){
const d = t(), bar = $("#authbar"), gate = $("#gate"), go = $("#go");
if(seasonClosed()){
// the server refuses these posts anyway; saying so here saves someone writing out an
// entry and being turned away after
bar.innerHTML = "";
gate.innerHTML = `<div class="lock">\u{1F6A7} ${d.season_notopen}</div>`;
go.disabled = true;
return;
}
if(ME.signed_in){
const u = ME.user || {};
bar.innerHTML = '<span class="u">' + (u.picture ? `<img src="${u.picture}" alt="">` : "")
+ (u.name||"") + `<a href="logout">${d.signout}</a></span>`;
gate.style.display = "none"; go.disabled = false;
}else{
bar.innerHTML = `<a class="hfbtn" href="login">\u{1F917} ${d.signin}</a>`;
// when OAuth is not configured (a local run) the form stays usable so the rest of
// the flow can still be exercised
const need = ME.oauth_configured;
gate.style.display = need ? "block" : "none";
gate.innerHTML = need ? d.gate + `<a class="hfbtn" href="login">\u{1F917} ${d.signin}</a>` : "";
go.disabled = need;
}
}
function renderModels(m){
const d = t();
$("#mcounts").textContent = d.mcounts(m.totals.models, m.totals.submissions);
$("#chart_sub").innerHTML = d.chart_sub;
$("#legend").innerHTML =
`<span><i style="background:linear-gradient(90deg,#0f7b6c,#2aa694)"></i>${d.lg_best}</span>`
+ `<span><i style="background:#123;width:3px;height:12px;border-radius:1px"></i>${d.lg_mean}</span>`
+ `<span><i style="background:#9db4d6"></i>${d.lg_use}</span>`;
if(!m.models.length){ $("#models").innerHTML = `<p class="who">${d.chart_empty}</p>`; return; }
const maxScore = Math.max(1, ...m.models.map(x=>x.best||0));
const maxUse = Math.max(1, ...m.models.map(x=>x.submissions||0));
$("#models").innerHTML = m.models.map(x=>
'<div class="mrow">'
+ `<div class="mname"${(x.spellings&&x.spellings.length>1)?` title="${esc(x.spellings.join(" ยท "))}"`:""}>`
+ `${esc(x.model)}${(x.spellings&&x.spellings.length>1)?` <b class="mmerge">+${x.spellings.length-1}</b>`:""}`
+ `<span>${x.entrants} ${d.entrants}</span></div>`
+ '<div class="mtrack">'
+ `<div class="best" style="width:${Math.max(4,(x.best||0)/maxScore*100)}%"></div>`
+ (x.mean!=null ? `<div class="mean" style="left:${Math.max(1,x.mean/maxScore*100)}%"></div>` : "")
+ `<div class="lab">${f3(x.best)}</div>`
+ '</div>'
+ '<div class="muse">'
+ `<span class="ub" style="width:${Math.max(3,(x.submissions/maxUse)*74)}px"></span>`
+ `<span class="un">${x.submissions}</span>`
+ '</div></div>').join("");
}
// The guide is per season, and it was not until 2026-08-19. PROMPTS was written for
// season 1 and every later season served it unchanged, so an entrant on the Chagas
// board pressed Copy and was handed a prompt beginning "You are designing
// small-molecule inhibitors of PfDHODH ... for an open antimalarial challenge". The
// point values in the subtitles were season 1's too. Nothing about the rubric moved
// here; the instructions were simply describing a different disease.
//
// Prompt E is shared on purpose - reading your own axis scores back into the next
// design is the same exercise whichever disease you are working on.
const PROMPTS_BY_SEASON = {
1: [{id:"A", ko:["๊ธฐ๋ณธํ","์ฒ์ ์์ํ๋ค๋ฉด ์ด๊ฒ๋ถํฐ"], en:["Starter","Begin here"],
body:`You are designing small-molecule inhibitors of PfDHODH, the dihydroorotate
dehydrogenase of Plasmodium falciparum, for an open antimalarial challenge.
Requirements:
- The compound must inhibit the PARASITE enzyme and NOT the human DHODH. The human
enzyme is homologous; inhibiting it causes immunosuppression rather than a cure.
- It has to kill the parasite in a whole cell, which means crossing a red blood cell
membrane and then the parasite membrane before the target is reachable.
- Molecular weight under 500. No PAINS motifs. No covalent warheads. Synthesisable.
Propose 8 candidates as a JSON array:
[{"smiles":"...","name":"...","rationale":"why this should be selective for the
parasite enzyme and reach it in a cell"}]
<em>VARY THIS: state a chemotype you are interested in, or a constraint of your own, so
your set does not collide with other entrants. Identical submissions are rejected.</em>`},
{id:"B", ko:["์ ํ์ฑ ์ง์ค","์ฌ๋ ํจ์๋ฅผ ํผํ๋ ์ค๊ณ (20์ )"], en:["Selectivity","Avoid the human enzyme (20 pts)"],
body:`Design PfDHODH inhibitors with a deliberate selectivity argument against human
DHODH.
Context you should reason from:
- Teriflunomide and brequinar inhibit the HUMAN enzyme. They are the failure mode here,
not the template.
- The inhibitor-binding site of the parasite enzyme differs from the human one in
residue composition and shape. Design into that difference on purpose and say which
difference you are exploiting.
- A molecule that binds neither enzyme is trivially "selective" and worthless. Potency
against the parasite enzyme is a precondition, not a trade-off.
For each candidate, state explicitly: which feature you expect the human enzyme to
tolerate poorly, and why.
Propose 8 candidates as JSON: [{"smiles","name","rationale"}]
<em>VARY THIS: pick one specific selectivity hypothesis and build the whole set around
it, rather than eight unrelated guesses.</em>`},
{id:"C", ko:["์ ๊ท ๊ณจ๊ฒฉ","๊ฐ์ฅ ํฐ ์ ์ ์ฌ์ง (์ ๊ท์ฑ 10์ )"], en:["Novel scaffold","Where the headroom is (10 pts)"],
body:`Design PfDHODH inhibitors on scaffolds that do NOT appear in the antimalarial
literature.
Why this matters for scoring: novelty is measured as structural distance from known
antimalarial chemical space, and it is MULTIPLIED by how potent the molecule is.
- A novel but inactive molecule earns nothing.
- A potent analogue of a known drug also earns nothing - the reference compound itself
scores zero on novelty, and an analogue inherits that.
- The points are only available to something both new and real.
Explicitly avoid: DSM265 and other triazolopyrimidines, Genz-667348, and published
PfDHODH inhibitor series. Do not decorate a known core - change the core.
Propose 8 candidates on eight DIFFERENT cores, as JSON:
[{"smiles","name","rationale":"why this core is unexplored here and why it should still
bind"}]
<em>VARY THIS: name two or three ring systems you want explored, so your set is yours.</em>`},
{id:"D", ko:["์ ์ธํฌ ํฌ๊ณผ","์ด์ค๋ง์ ํต๊ณผํด์ผ ํ๋ค (30์ )"], en:["Whole-cell","Two membranes to cross (30 pts)"],
body:`Design PfDHODH inhibitors optimised for actually killing the parasite in an
infected red blood cell, not just for binding the isolated enzyme.
The compound must cross the erythrocyte membrane and then the parasite membrane before
the target matters. Enzyme affinity that never reaches the enzyme scores nothing.
Reason explicitly about, for each candidate:
- lipophilicity and polar surface area in a range compatible with passive permeability
- the number of hydrogen-bond donors, and whether it is low enough
- ionisation at the pH of the parasite's compartments
- metabolic stability - the compound must survive long enough to matter
Propose 8 candidates as JSON: [{"smiles","name","rationale":"the permeability argument,
not only the binding argument"}]
<em>VARY THIS: fix your own target property window before generating, and hold the set
to it.</em>`},
{id:"E", ko:["์ ์ ๋๋จน์ด๊ธฐ","๋ฐ์ ๊ฒฐ๊ณผ๋ก ๋ค์ ํ์ ์ค๊ณ"], en:["Iterate","Feed your score back in"],
body:`Here is how my previous candidate was scored on this challenge. Improve on it.
PASTE YOUR RESULT HERE - hover your row on the leaderboard and copy the numbers:
candidate id, total, and the six axis scores with their stated reasons
(predicted potency against each enzyme, the selectivity ratio, the nearest known
compound, the synthesis difficulty)
Diagnose which axis is costing the most, then propose 8 revised candidates that attack
that axis specifically, while not giving back what already scored well.
Be honest about trade-offs: if improving selectivity is likely to cost whole-cell
activity, say so and show both options.
JSON: [{"smiles","name","rationale":"which axis this targets and what it trades"}]
<em>VARY THIS: your own scores make this prompt unique - no two entrants have the
same starting point.</em>`},
],
2: [
{id:"A", ko:["๊ธฐ๋ณธํ","์ฒ์ ์์ํ๋ค๋ฉด ์ด๊ฒ๋ถํฐ"], en:["Starter","Begin here"],
body:`You are designing small-molecule inhibitors of InhA, the enoyl-ACP reductase of
Mycobacterium tuberculosis, for an open tuberculosis challenge.
Requirements:
- The compound must inhibit the BACTERIAL enzyme and NOT the enoyl-reductase domain of
human fatty acid synthase. The human enzyme runs the same chemistry; inhibiting it
stops our own fatty-acid synthesis.
- InhA works as a complex with NAD. Inhibitors that stack against the bound cofactor are
a well-trodden route.
- It has to work in a whole cell. M. tuberculosis has an unusually thick, waxy cell wall,
so permeability is a harder constraint here than in most bacteria.
- Do NOT submit a prodrug. Isoniazid is inactive until the bacterium's own KatG converts
it; we score the molecule you submit, not what it might become.
- Molecular weight under 550. No PAINS motifs. Synthesisable.
Propose 8 candidates as a JSON array:
[{"smiles":"...","name":"...","rationale":"why this should be selective for the
bacterial enzyme and reach it through the mycobacterial cell wall"}]
<em>VARY THIS: state a chemotype you are interested in, or a constraint of your own, so
your set does not collide with other entrants. Identical submissions are rejected.</em>`},
{id:"B", ko:["์ ํ์ฑ ์ง์ค","์ฌ๋ ํจ์๋ฅผ ํผํ๋ ์ค๊ณ (25์ )"], en:["Selectivity","Avoid the human enzyme (25 pts)"],
body:`Design InhA inhibitors with a deliberate selectivity argument against the enoyl-reductase
domain of human fatty acid synthase.
Context you should reason from:
- Both enzymes reduce an enoyl thioester using NAD(P)H. The chemistry is shared; the
surroundings are not.
- InhA accepts very long-chain (C16-C24) substrates and has a correspondingly large,
hydrophobic substrate-binding loop. Human FASN handles shorter chains. Design into that
difference on purpose and say which difference you are exploiting.
- A molecule that binds neither enzyme is trivially "selective" and worthless. Potency
against InhA is scored separately and selectivity is scaled by it.
Return 8 candidates as JSON with a "selectivity_rationale" field naming the specific
structural feature you are exploiting.`},
{id:"C", ko:["์ ๊ท ๊ณจ๊ฒฉ","๊ฐ์ฅ ํฐ ์ ์ ์ฌ์ง (์ ๊ท์ฑ 10์ )"], en:["Novel scaffold","Where the headroom is (10 pts)"],
body:`Propose InhA inhibitors on scaffolds that are NOT represented among known
anti-tubercular chemistry.
Explicitly avoid: isoniazid-like hydrazides, thioamides (ethionamide, prothionamide),
diarylquinolines, nitroimidazoles, oxazolidinones (linezolid-like) and fluoroquinolones.
Novelty is scored as distance from known anti-tubercular chemical space, and it is
MULTIPLIED by potency - a novel molecule that does nothing scores zero on that axis. So
the target is a genuinely new scaffold that still makes a credible binding argument
against the InhA-NAD complex.
Return 8 candidates as JSON, each with the scaffold class named and one sentence on why
it can still engage the site.`},
{id:"D", ko:["์ ์ธํฌ ํ์ฑ","๋ฐ๋ ์ธํฌ๋ฒฝ์ ํต๊ณผํด์ผ ํ๋ค (20์ )"], en:["Whole-cell","Through a waxy wall (20 pts)"],
body:`Design InhA inhibitors with mycobacterial cell entry as the primary constraint.
What makes this hard:
- The mycobacterial envelope is a thick mycolic-acid layer, far less permeable than a
typical Gram-negative outer membrane. Many potent enzyme inhibitors fail entirely at
the whole-cell step.
- Efflux is active in M. tuberculosis and removes many otherwise good compounds.
- Compounds are scored on whole-cell growth inhibition as well as on binding, so an
inhibitor that cannot get in is scored as what it is.
Return 8 candidates as JSON with a "permeability_rationale" field. State the logP,
polar surface area and any efflux-avoidance reasoning you used.`},
{id:"E", ko:["์ ์ ๋๋จน์ด๊ธฐ","๋ฐ์ ๊ฒฐ๊ณผ๋ก ๋ค์ ํ์ ์ค๊ณ"], en:["Iterate","Feed your score back in"],
body:`Here is how my previous candidate was scored on this challenge. Improve on it.
PASTE YOUR RESULT HERE - hover your row on the leaderboard and copy the numbers:
candidate id, total, and the six axis scores with their stated reasons
(predicted potency against each enzyme, the selectivity ratio, the nearest known
compound, the synthesis difficulty)
Diagnose which axis is costing the most, then propose 8 revised candidates that attack
that axis specifically, while not giving back what already scored well.
Be honest about trade-offs: if improving selectivity is likely to cost whole-cell
activity, say so and show both options.
JSON: [{"smiles","name","rationale":"which axis this targets and what it trades"}]
<em>VARY THIS: your own scores make this prompt unique - no two entrants have the
same starting point.</em>`}
],
3: [
{id:"A", ko:["๊ธฐ๋ณธํ","์ฒ์ ์์ํ๋ค๋ฉด ์ด๊ฒ๋ถํฐ"], en:["Starter","Begin here"],
body:`You are designing small-molecule inhibitors of CYP51, the sterol 14a-demethylase of
Trypanosoma cruzi, for an open Chagas disease challenge.
Requirements:
- The compound must inhibit the PARASITE enzyme and NOT human CYP51A1. We run the same
enzyme on the same chemistry, and inhibiting it is where the azole antifungals get
their side effects.
- CYP51 is a haem enzyme. Inhibitors classically coordinate the haem iron through a ring
nitrogen. A molecule that does only that will not be selective, because our enzyme has
the same iron - the selectivity has to come from somewhere else.
- It has to work in a whole cell. T. cruzi persists inside host cells as an amastigote,
so the compound must cross the host cell membrane and then the parasite's.
- Do NOT submit a prodrug. Benznidazole and nifurtimox are nitro compounds activated by
a parasite nitroreductase; we score the molecule you submit, not what it becomes.
- Molecular weight under 750. Synthesisable.
Propose 8 candidates as a JSON array:
[{"smiles":"...","name":"...","rationale":"why this should be selective for the parasite
enzyme and reach it inside a host cell"}]
<em>VARY THIS: state a chemotype you are interested in, or a constraint of your own, so
your set does not collide with other entrants. Identical submissions are rejected.</em>`},
{id:"B", ko:["์ ํ์ฑ ์ง์ค","์ฌ๋ ํจ์๋ฅผ ํผํ๋ ์ค๊ณ (30์ )"], en:["Selectivity","Avoid the human enzyme (30 pts)"],
body:`Design T. cruzi CYP51 inhibitors with a deliberate selectivity argument against human
CYP51A1.
Context you should reason from:
- Both enzymes strip the 14a-methyl group off a sterol precursor at a haem iron. The
catalysis is shared; the channel that admits the substrate is not.
- The parasite makes ergosterol-like sterols and we make cholesterol by way of
lanosterol, and the hydrophobic substrate channels differ accordingly. Design into that
difference on purpose and name the difference you are exploiting.
- This is the axis nobody has cleared. The approved azoles inhibit the human enzyme about
as hard as the parasite's, which is why they are tolerated the way they are. Matching
them is not the target.
- A molecule that binds neither enzyme is trivially "selective" and worthless. Potency
against the parasite enzyme is scored separately and selectivity is scaled by it.
Return 8 candidates as JSON with a "selectivity_rationale" field naming the specific
structural feature you are exploiting.`},
{id:"C", ko:["์ ๊ท ๊ณจ๊ฒฉ","๊ฐ์ฅ ํฐ ์ ์ ์ฌ์ง (์ ๊ท์ฑ 10์ )"], en:["Novel scaffold","Where the headroom is (10 pts)"],
body:`Propose T. cruzi CYP51 inhibitors on scaffolds that are NOT represented among known
anti-trypanosomal chemistry.
Explicitly avoid: imidazole and triazole azoles of the ketoconazole or posaconazole type,
nitroimidazoles and nitrofurans, and close analogues of either.
Novelty is scored as distance from known anti-T. cruzi chemical space, and it is
MULTIPLIED by potency - a novel molecule that does nothing scores zero on that axis. So
the target is a genuinely new scaffold that still makes a credible argument for engaging
a haem-containing active site.
Return 8 candidates as JSON, each with the scaffold class named and one sentence on why
it can still engage the site.`},
{id:"D", ko:["์ ์ธํฌ ํ์ฑ","์์ฃผ ์ธํฌ ์๊น์ง ๋ค์ด๊ฐ์ผ ํ๋ค (10์ )"], en:["Whole-cell","Reach inside a host cell (10 pts)"],
body:`Design T. cruzi CYP51 inhibitors with entry into an infected host cell as the primary
constraint.
What makes this hard:
- T. cruzi persists as an intracellular amastigote, most importantly in cardiac muscle.
A compound has to cross the host cell membrane and then reach the parasite inside it.
- Chronic Chagas disease is treated for weeks to months. A compound that only works at a
concentration nobody can sustain is not a candidate.
- Compounds are scored on whole-cell growth inhibition as well as on binding, so an
inhibitor that cannot get in is scored as what it is.
Return 8 candidates as JSON with a "permeability_rationale" field. State the logP, polar
surface area and any reasoning about intracellular accumulation you used.`},
{id:"E", ko:["์ ์ ๋๋จน์ด๊ธฐ","๋ฐ์ ๊ฒฐ๊ณผ๋ก ๋ค์ ํ์ ์ค๊ณ"], en:["Iterate","Feed your score back in"],
body:`Here is how my previous candidate was scored on this challenge. Improve on it.
PASTE YOUR RESULT HERE - hover your row on the leaderboard and copy the numbers:
candidate id, total, and the six axis scores with their stated reasons
(predicted potency against each enzyme, the selectivity ratio, the nearest known
compound, the synthesis difficulty)
Diagnose which axis is costing the most, then propose 8 revised candidates that attack
that axis specifically, while not giving back what already scored well.
Be honest about trade-offs: if improving selectivity is likely to cost whole-cell
activity, say so and show both options.
JSON: [{"smiles","name","rationale":"which axis this targets and what it trades"}]
<em>VARY THIS: your own scores make this prompt unique - no two entrants have the
same starting point.</em>`}
]
};
function promptsFor(){ return PROMPTS_BY_SEASON[SEASON] || PROMPTS_BY_SEASON[1]; }
// Listed under the slugs Polaris itself uses, so each one can be looked up rather than
// taken on trust. All sixteen were checked against the live Polaris benchmark index.
// The sixteenth - adme-fang-perm - is the Biogen ADME permeability track, described
// there as "LOG_MDR1-MDCK_ER"; it postdates the engine's own capability list, which is
// why that list still reads fifteen.
const BOARDS = ["hia-hou","bioavailability-ma","vdss-lombardo","solubility-aqsoldb",
"cyp2d6-substrate-carbonmangels","ames","dili","moleculeace-chembl234-ki",
"moleculeace-chembl236-ki","pkis2-egfr-wt-reg-v2","pkis2-egfr-wt-r-1",
"pkis1-egfr-wt-mut-r-1","pkis1-egfr-wt-mut-c-1","pkis2-lok-slk-c-1",
"pkis1-kit-wt-mut-r-1","adme-fang-perm"];
function reasonText(r){
// r is {code, arg, limit, text}; older records may still be a bare string
if(typeof r === "string") return r;
const f = t().reasons[r.code];
return f ? f(r) : (r.text || r.code || "");
}
const OV = document.getElementById("ov");
const WMAX = {activity:30, binding:20, selectivity:20, admet:15, novelty:10, synthesis:5};
function ic50(logUM){
// boltz reports log10(IC50 in uM); show it in whichever unit reads naturally
if(logUM==null) return "โ";
const uM = Math.pow(10, logUM);
return uM < 1 ? (uM*1000).toFixed(1)+" nM" : uM.toFixed(2)+" \u00B5M";
}
// falls back to the Korean note rather than to nothing: a reference row with no
// explanation beside it is worse than one explained in the other language
function anchorNote(e){
return (LANG === "en" ? (e.note_en || e.note) : e.note) || "";
}
function overlayHTML(e){
const d = t(), det = e.detail || {}, ax = e.axes || {};
if(!Object.keys(ax).length) return `<h4>${e.candidate_id}</h4><div class="oid">${d.ov_none}</div>`;
const rows = Object.keys(WMAX).map(k=>{
const pts = ax[k], max = WMAX[k];
const why = (det[k] && d.ov_why[k]) ? d.ov_why[k](det[k]) : "";
return `<div class="orow"><span class="oax">${d.ov_axes[k]}</span>
<span class="obar"><i style="width:${Math.max(2,(pts||0)/max*100)}%"></i></span>
<span class="opt">${(pts??0).toFixed(1)}</span>
${why?`<span class="why">${why}</span>`:""}</div>`;
}).join("");
const r = e.run || {}, sel = det.selectivity || {};
const pred = (r.aff_pf!=null || r.aff_hs!=null) ? `<div class="osum">
${d.ov_pred} ยท ${d.ov_pf} <b>${ic50(r.aff_pf)}</b> ยท ${d.ov_hs} <b>${ic50(r.aff_hs)}</b>
${sel.fold?` ยท ${d.ov_sel} <b>${sel.fold}x</b>`:""}</div>` : "";
const flag = (e.relegate_reason && e.relegate_reason.length)
? `<div class="oflag">${e.relegate_reason.map(reasonText).join(" / ")}</div>` : "";
const who = e.is_anchor ? anchorNote(e) : [e.hf_user, e.model_name].filter(Boolean).join(" ยท ");
const full = (e.visibility === "public" && e.smiles) ? e.smiles : e.smiles_masked;
const canCopy = e.visibility === "public" && e.smiles;
const smi = e.is_anchor ? ""
: `<div class="osmi">${full || ""}`
+ (canCopy ? `<button class="d3" data-smi="${e.smiles}" title="${d.view_3d}">3D</button>`
+ `<button class="cp" data-smi="${e.smiles}" title="${d.copy_smiles}">\u29c9</button>` : "")
+ (e.visibility === "public" ? "" : `<br>๐ ${d.private_full}`) + `</div>`;
return `<h4>${e.candidate_id}</h4><div class="oid">${who}${e.skeleton?" ยท "+e.skeleton:""}</div>`
+ rows + pred + smi + flag + `<div class="ofoot">${d.ov_foot}</div>`;
}
// ---------------------------------------------------------------- ์ด์ ํ
// ๐ด ์ซ์๋ฅผ ๋ฌธ๊ตฌ์ ๋ฐ์ง ์๋๋ค. ์ ์ถ์ ์๊ฐ๋น ์์ญ ๊ฑด์ฉ ๋ค์ด์์, ๋ฐ์๋๋ฉด
// ๋ฐ๋์ ๋ง์ ๋ก์ ๊ฐ์ด ๊ณต๊ฐ๋ฉด์ ๋จ๋๋ค. /api/totals ๋ฅผ ์ฝ์ด ๊ทธ๋๊ทธ๋ ๊ทธ๋ฆฐ๋ค.
async function paintMilestone(){
const el = document.getElementById("milestone");
if (!el) return;
let d; try{ d = await j("/api/totals"); }catch(e){ return; }
if (!d || !d.submissions || d.submissions < 10000) return; // ๋ชป ๋์์ผ๋ฉด ๋์ฐ์ง ์๋๋ค
const n = d.submissions.toLocaleString();
const p = (d.participants||0).toLocaleString();
const days = d.days;
el.innerHTML = (LANG==="ko")
? `๐ <b>ํ๋ณด๋ฌผ์ง <span class="n">${n}</span>๊ฑด์ ๋์์ต๋๋ค.</b> ๊ฐ๋ง ${days}์ผ, ์ฐธ๊ฐ์ ${p}๋ช
์ด ๋ธ ๊ฒ์
๋๋ค.
์๋ก ์์ง๋ ๋ชปํ๋ ๋ถ๋ค์ด ๊ฐ์ ๊ธฐ์ค์ผ๋ก ๊ฒจ๋ค ๋ง๋ ์ซ์์
๋๋ค. ๊ณ ๋ง์ต๋๋ค.`
: `๐ <b>Past <span class="n">${n}</span> candidate molecules.</b> ${days} days in, from ${p} participants โ
people who mostly do not know each other, measured on one rubric. Thank you.`;
el.hidden = false;
}
// ---------------------------------------------------------------- countdown
// end of the closing day, UTC. A deadline that lands at a different instant depending on
// the entrant's timezone is not one, and the prize hangs off this date.
let _deadline = null;
function startCountdown(closes){
const t = Date.parse(closes + "T23:59:59Z");
if(isNaN(t)) return;
_deadline = t;
tickCountdown();
clearInterval(startCountdown._i);
startCountdown._i = setInterval(tickCountdown, 1000);
}
function tickCountdown(){
if(!_deadline) return;
const d = t(), box = $("#cd");
// recomputed from the clock each tick rather than decremented, so a throttled or
// suspended background tab comes back showing the right number instead of its own drift
let ms = _deadline - Date.now();
$("#cdlab").textContent = ms > 0 ? d.cd_label : d.cd_over_label;
if(ms <= 0){
box.classList.add("over");
$("#cdval").textContent = d.cd_over;
clearInterval(startCountdown._i);
return;
}
box.classList.remove("over");
const s = Math.floor(ms / 1000);
const days = Math.floor(s / 86400);
const p = n => String(n).padStart(2, "0");
// ๋ผ๋ฒจ์ด ์ด๋ฏธ "๋ง๊ฐ๊น์ง" ๋ผ๊ณ ๋งํ๋ค. ์์ ๋นผ๊ธฐ ๊ธฐํธ๋ฅผ ๋ถ์ฌ ๋์ด์ ๋จ์ ๋ ์ด
// ์์์ฒ๋ผ ๋ณด์๋ค - 156์ผ ๋จ์๋๋ฐ "-156์ผ" ๋ก ์ฝํ๋ค.
$("#cdval").innerHTML = `${days}<span class="d">${d.cd_day}</span> `
+ `${p(Math.floor(s % 86400 / 3600))}:${p(Math.floor(s % 3600 / 60))}:${p(s % 60)}`;
}
// ---------------------------------------------------------------- 3D viewer
// 3Dmol is loaded on first use. It is ~2 MB and most visits never open a structure, so
// paying for it on every page load would be charging everyone for a minority feature.
let _v3 = null, _3ready = null, _spin = true, _style = "stick";
// out of the grid and onto the body: the modal was declared beside the hover overlay,
// inside the layout, and the grid's min-width:0 collapsed it to nothing
document.body.appendChild($("#m3"));
function load3Dmol(){
if(_3ready) return _3ready;
_3ready = new Promise((res, rej) => {
const s = document.createElement("script");
s.src = "https://3Dmol.org/build/3Dmol-min.js";
s.onload = res; s.onerror = () => rej(new Error("3Dmol"));
document.head.appendChild(s);
});
return _3ready;
}
function paint3(){
if(!_v3) return;
_v3.setStyle({}, _style === "sphere"
? {sphere:{scale:0.42, colorscheme:"Jmol"}}
: {stick:{radius:0.17, colorscheme:"Jmol"}, sphere:{scale:0.22, colorscheme:"Jmol"}});
_v3.render();
}
async function open3D(smi){
const M = $("#m3"), msg = $("#m3m");
M.classList.add("on");
$("#m3s").textContent = smi;
$("#m3f").textContent = ""; $("#m3w").textContent = "";
msg.textContent = t().v3_loading;
try{
const [_, r] = await Promise.all([
load3Dmol(),
fetch("api/mol3d?smiles=" + encodeURIComponent(smi)).then(x => x.json())
]);
if(!r.mol) throw new Error("mol");
$("#m3f").textContent = r.formula;
$("#m3w").textContent = r.mw + " Da \u00b7 " + r.atoms + " " + t().v3_atoms;
const host = $("#m3v");
host.innerHTML = "";
_v3 = $3Dmol.createViewer(host, {backgroundColor:"#0d1420"});
_v3.addModel(r.mol, "mol");
paint3();
_v3.zoomTo();
_v3.render();
_v3.spin(_spin ? "y" : false, 0.6);
msg.textContent = "";
}catch(err){
msg.textContent = t().v3_failed;
}
}
function close3D(){
$("#m3").classList.remove("on");
// the WebGL context is not reclaimed by hiding the element; leaving one per open would
// eventually exhaust the browser's context budget and blank the canvas
try{ if(_v3){ _v3.spin(false); _v3.clear(); } }catch(_){}
_v3 = null; $("#m3v").innerHTML = "";
}
$("#m3x").onclick = close3D;
$("#m3").onclick = (e) => { if(e.target.id === "m3") close3D(); };
document.addEventListener("keydown", e => { if(e.key === "Escape") close3D(); });
$("#m3st").onclick = () => { _style = "stick"; $("#m3st").classList.add("on");
$("#m3sp").classList.remove("on"); paint3(); };
$("#m3sp").onclick = () => { _style = "sphere"; $("#m3sp").classList.add("on");
$("#m3st").classList.remove("on"); paint3(); };
$("#m3rt").onclick = () => { _spin = !_spin; $("#m3rt").classList.toggle("on", _spin);
try{ if(_v3) _v3.spin(_spin ? "y" : false, 0.6); }catch(_){} };
function wire3D(root){
root.querySelectorAll(".d3").forEach(b => b.onclick = (ev) => {
ev.stopPropagation();
open3D(b.dataset.smi);
});
}
function wireCopy(root){
root.querySelectorAll(".cp").forEach(b => b.onclick = async (ev) => {
// without this the click also reaches the row and toggles the overlay
ev.stopPropagation();
const v = b.dataset.smi;
try{ await navigator.clipboard.writeText(v); }
catch(_){ const ta=document.createElement("textarea"); ta.value=v;
document.body.appendChild(ta); ta.select(); document.execCommand("copy"); ta.remove(); }
b.classList.add("done"); b.textContent = "\u2713";
setTimeout(()=>{ b.classList.remove("done"); b.textContent = "\u29c9"; }, 1200);
});
}
function showOverlay(e, rect){
OV.innerHTML = overlayHTML(e);
OV.style.display = "block";
const h = OV.offsetHeight, w = OV.offsetWidth;
// flip above the row rather than open past the bottom of the window
let top = rect.bottom + 8;
if(top + h > window.innerHeight - 8) top = Math.max(8, rect.top - h - 8);
// anchor to the right of the row: the structure and its copy button live on the left,
// and opening over them buries the control the reader was reaching for
let left = Math.max(8, Math.min(rect.right - w, window.innerWidth - w - 12));
OV.style.top = top + "px";
OV.style.left = left + "px";
wireCopy(OV);
wire3D(OV);
}
function hideOverlay(){ OV.style.display = "none"; }
OV.onmouseenter = () => clearTimeout(OV._t);
OV.onmouseleave = hideOverlay;
async function load(){
try{
const [lb, me, md] = await Promise.all([
fetch("api/leaderboard" + qs()).then(r=>r.json()),
fetch("api/me").then(r=>r.json()).catch(()=>ME),
fetch("api/models" + qs()).then(r=>r.json()).catch(()=>MODELS),
]);
DATA = lb; ME = me; MODELS = md;
if(DATA.season && DATA.season.closes) startCountdown(DATA.season.closes);
renderAuth(); render(); renderModels(MODELS);
paintMilestone(); // ์คํจํด๋ ๋ณธ๋ฌธ์ ๊ทธ๋ ค์ ธ์ผ ํ๋ฏ๋ก await ํ์ง ์๋๋ค
}
catch(e){ $("#rows").innerHTML = `<tr><td colspan="11" class="who">${t().fail}${e}</td></tr>`; }
}
$("#go").onclick = async ()=>{
const d = t(), btn = $("#go"), msg = $("#msg");
const vis = (document.querySelector('input[name="vis"]:checked')||{}).value || "private";
const body = {structure:$("#structure").value.trim(), display_name:$("#display_name").value.trim(),
model_name:$("#model_name").value.trim(), rationale:$("#rationale").value.trim(),
visibility: vis, season: SEASON};
if(!body.structure || !body.display_name){ msg.className="msg err"; msg.textContent=d.need; return; }
btn.disabled = true; msg.className="msg"; msg.textContent="";
try{
const r = await fetch("api/submit" + qs(),{method:"POST",headers:{"Content-Type":"application/json"},body:JSON.stringify(body)});
// ์๋ฒ๊ฐ JSON ์ด ์๋ ๊ฒ์ ๋๋ ค์ค ์ ์๋ค - ๊ฒ์ดํธ์จ์ด ์ค๋ฅ ๋ณธ๋ฌธ์ HTML ์ด๋ค.
// ๊ทธ๋๋ก ํ์ฑํ๋ฉด ์ฐธ๊ฐ์์๊ฒ "Unexpected token 'I'" ๊ฐ ๋ฌ๋ค. ๋ฌด์จ ์ผ์ด ๋ฌ๋์ง๋,
// ๋ค์ ๋ด๋ฉด ๋๋์ง๋ ์๋ ค์ฃผ์ง ์๋ ๋ฌธ์ฅ์ด๋ค.
let j = null;
try{ j = await r.json(); }catch(_){ j = null; }
if(!j){ msg.className="msg err"; msg.textContent = r.status>=500 ? d.busy : (d.fail+r.status);
btn.disabled=false; return; }
if(j.accepted){ msg.className="msg ok"; msg.textContent=d.queued(j.candidate_id,j.queue_position,j.note);
$("#structure").value=""; load(); }
else { msg.className="msg err";
msg.textContent=(j.reasons||[]).map(reasonText).join(" / ") || d.rejected; }
}catch(e){ msg.className="msg err"; msg.textContent=d.fail+e; }
btn.disabled = false;
};
document.querySelectorAll('input[name="vis"]').forEach(r => r.onchange = () => {
$("#vis_priv").classList.toggle("on", r.value === "private" ? r.checked : !r.checked);
$("#vis_pub").classList.toggle("on", r.value === "public" ? r.checked : !r.checked);
});
function renderPrompts(){
const d = t(), host = $("#prompts");
if(!host) return;
host.innerHTML = promptsFor().map((p,i) => {
const [title, sub] = (LANG==="ko" ? p.ko : p.en);
return `<div class="pcard">
<div class="phead"><span class="ptag">${p.id}</span>
<b>${title}</b><span>${sub}</span>
<button class="pcopy" data-i="${i}">${LANG==="ko"?"๋ณต์ฌ":"Copy"}</button></div>
<div class="pbody">${p.body.trim()}</div></div>`;
}).join("");
host.querySelectorAll(".pcopy").forEach(b => b.onclick = async () => {
// the emphasis markup is presentational; the clipboard gets clean text
const raw = promptsFor()[+b.dataset.i].body.replace(/<\/?em>/g, "").trim();
try{ await navigator.clipboard.writeText(raw); }
catch(_){ const ta=document.createElement("textarea"); ta.value=raw;
document.body.appendChild(ta); ta.select(); document.execCommand("copy"); ta.remove(); }
const was = b.textContent;
b.textContent = LANG==="ko" ? "๋ณต์ฌ๋จ โ" : "Copied โ";
setTimeout(()=>{ b.textContent = was; }, 1500);
});
}
function seasonFacts(){
const si = seasonInfo() || {}, d = t();
const W = si.weights || {}, L = si.limits || {};
const names = LANG==="ko"
? {activity:"์ฝํจ", binding:"๊ฒฐํฉ", selectivity:"์ ํ์ฑ", admet:"ADMET",
novelty:"์ ๊ท์ฑ", synthesis:"ํฉ์ฑ"}
: {activity:"Activity", binding:"Binding", selectivity:"Selectivity", admet:"ADMET",
novelty:"Novelty", synthesis:"Synthesis"};
const order = ["activity","binding","selectivity","admet","novelty","synthesis"];
const line = order.filter(k => W[k] != null).map(k => names[k] + " " + W[k]).join(" ยท ");
const total = order.reduce((a,k) => a + (W[k]||0), 0);
return {
WEIGHTS: line + (LANG==="ko" ? `, ํฉ๊ณ ${total}์ ์
๋๋ค.` : `, out of ${total}.`),
MW: L.mw_max != null ? String(Math.round(L.mw_max)) : "550"
};
}
function fillFacts(text){
if(!text) return text;
const f = seasonFacts();
return String(text).replace(/\{(WEIGHTS|MW)\}/g, (_, k) => f[k]);
}
function renderFails(){
const d = t(), host = $("#fails");
if(!host) return;
host.innerHTML = (d.fails||[]).map(([a,b]) => `<tr><td>${fillFacts(a)}</td><td>${fillFacts(b)}</td></tr>`).join("");
}
document.querySelectorAll("#tabs button").forEach(b => b.onclick = () => {
document.querySelectorAll("#tabs button").forEach(x => x.classList.toggle("on", x===b));
document.querySelectorAll(".panel").forEach(p =>
p.classList.toggle("on", p.id === "p-" + b.dataset.panel));
hideOverlay();
window.scrollTo({top:0, behavior:"smooth"});
});
window.addEventListener("scroll", hideOverlay, {passive:true});
window.addEventListener("resize", hideOverlay);
fetch("api/seasons").then(r=>r.json()).then(j=>{ SEASONS = j.seasons; applyLang(); loadTally(); })
.catch(()=>{});
setInterval(loadTally, 600000);
applyLang(); load(); setInterval(load, 20000);
</script>
</body>
</html>
|